ONECUT1
Gene Information
- Official Symbol: ONECUT1
- Official Name: one cut homeobox 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 3175
- UniProt: Q9UBC0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcriptional activator. Binds the consensus sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Important for liver genes transcription.
Pfam Domains GO Terms
Pfam Domains
| Homeobox |
| CUT |
GO Terms
| spleen development |
| endocrine pancreas development |
| pancreas development |
| negative regulation of transforming growth factor beta receptor signaling pathway |
| endoderm development |
| negative regulation of cellular response to transforming growth factor beta stimulus |
| B cell differentiation |
| glucose metabolic process |
| regulation of transforming growth factor beta receptor signaling pathway |
| regulation of cell-matrix adhesion |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of cellular response to transforming growth factor beta stimulus |
| endocrine system development |
| liver development |
| Notch signaling pathway |
| hepaticobiliary system development |
| negative regulation of cellular response to growth factor stimulus |
| B cell activation |
| hexose metabolic process |
| epithelial cell development |
| monosaccharide metabolic process |
| regulation of cell-substrate adhesion |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| lymphocyte differentiation |
| cell fate commitment |
| regulation of cellular response to growth factor stimulus |
| leukocyte differentiation |
| cilium assembly |
| cilium organization |
| lymphocyte activation |
| gland development |
| plasma membrane bounded cell projection assembly |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| cell projection assembly |
| carbohydrate metabolic process |
| positive regulation of cell migration |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| hemopoiesis |
| hematopoietic or lymphoid organ development |
| immune system development |
| regulation of cell adhesion |
| epithelial cell differentiation |
| organelle assembly |
| regulation of cell migration |
| regulation of cell motility |
| leukocyte activation |
| regulation of locomotion |
| regulation of cellular component movement |
| cell activation |
| epithelium development |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of signal transduction |
| negative regulation of cell communication |
| negative regulation of signaling |
| DNA binding |
| positive regulation of transcription, DNA-templated |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of RNA metabolic process |
| small molecule metabolic process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10628
- Expression level (log2 read counts): 2.31
Expression Distribution
ONECUT1 Expression in NALM6 Cells: 2.31
