OPLAH

Gene Information

Official Symbol: OPLAH
Official Name: 5-oxoprolinase, ATP-hydrolysing
Aliases and Previous Symbols: N/A
Entrez ID: 26873
UniProt: O14841
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene acts as a homodimer, using ATP hydrolysis to catalyze the conversion of 5-oxo-L-proline to L-glutamate. Defects in this gene are a cause of 5-oxoprolinase deficiency (OPLAHD). [provided by RefSeq, Jun 2012].
UniProt Summary: Catalyzes the cleavage of 5-oxo-L-proline to form L- glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6

Essentiality Rank: 12025
Expression level (log2 read counts): -0.44

Expression Distribution