OSR1
Gene Information
- Official Symbol: OSR1
- Official Name: odd-skipped related transcription factor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 130497
- UniProt: Q8TAX0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Transcription factor that plays a role in the regulation of embryonic heart and urogenital development. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| renal vesicle progenitor cell differentiation |
| metanephric cap development |
| anterior mesonephric tubule development |
| specification of posterior mesonephric tubule identity |
| metanephric interstitial fibroblast development |
| metanephric cap mesenchymal cell proliferation involved in metanephros development |
| metanephric interstitial fibroblast differentiation |
| metanephric cap morphogenesis |
| specification of mesonephric tubule identity |
| specification of anterior mesonephric tubule identity |
| kidney interstitial fibroblast differentiation |
| negative regulation of creatine transmembrane transporter activity |
| anterior/posterior pattern specification involved in kidney development |
| pattern specification involved in mesonephros development |
| regulation of creatine transmembrane transporter activity |
| kidney smooth muscle tissue development |
| intermediate mesoderm development |
| metanephric smooth muscle tissue development |
| negative regulation of nephron tubule epithelial cell differentiation |
| renal interstitial fibroblast development |
| posterior mesonephric tubule development |
| embryonic skeletal limb joint morphogenesis |
| kidney mesenchyme morphogenesis |
| ureter urothelium development |
| limb joint morphogenesis |
| metanephric mesenchyme morphogenesis |
| pattern specification involved in metanephros development |
| mesonephric duct morphogenesis |
| specification of nephron tubule identity |
| proximal/distal pattern formation involved in nephron development |
| metanephric mesenchymal cell differentiation |
| negative regulation of epithelial cell differentiation involved in kidney development |
| metanephric glomerulus vasculature development |
| mesangial cell development |
| mesangial cell differentiation |
| cell proliferation involved in metanephros development |
| mesonephric tubule formation |
| positive regulation of gastrulation |
| pericyte cell differentiation |
| mesenchymal cell differentiation involved in renal system development |
| mesenchymal cell differentiation involved in kidney development |
| pattern specification involved in kidney development |
| renal system pattern specification |
| pronephros development |
| mesonephric duct development |
| cell proliferation involved in kidney development |
| metanephric glomerulus development |
| embryonic skeletal joint morphogenesis |
| nephric duct morphogenesis |
| negative regulation of sodium ion transmembrane transporter activity |
| regulation of nephron tubule epithelial cell differentiation |
| renal vesicle development |
| negative regulation of sodium ion transmembrane transport |
| negative regulation of anion transmembrane transport |
| metanephric mesenchyme development |
| embryonic skeletal joint development |
| metanephric nephron tubule development |
| ureter development |
| nephric duct development |
| mesenchymal cell proliferation |
| negative regulation of kidney development |
| nephron tubule formation |
| metanephric nephron epithelium development |
| smooth muscle tissue development |
| segment specification |
| cell differentiation involved in metanephros development |
| glomerulus vasculature development |
| kidney mesenchyme development |
| negative regulation of sodium ion transport |
| metanephric tubule development |
| regulation of epithelial cell differentiation involved in kidney development |
| middle ear morphogenesis |
| kidney vasculature development |
| renal system vasculature development |
| negative regulation of organic acid transport |
| metanephric epithelium development |
| regulation of anion transmembrane transport |
| negative regulation of anion transport |
| negative regulation of response to drug |
| embryonic hindlimb morphogenesis |
| metanephric nephron development |
| proximal/distal pattern formation |
| embryonic forelimb morphogenesis |
| hindlimb morphogenesis |
| regulation of gastrulation |
| positive regulation of embryonic development |
| positive regulation of bone mineralization |
| cell differentiation involved in kidney development |
| negative regulation of epithelial cell differentiation |
| forelimb morphogenesis |
| positive regulation of biomineralization |
| positive regulation of biomineral tissue development |
| mesenchyme morphogenesis |
| glomerulus development |
| regulation of sodium ion transmembrane transporter activity |
| mesonephric tubule morphogenesis |
| regulation of kidney development |
| regulation of organic acid transport |
| embryonic digit morphogenesis |
| regulation of sodium ion transmembrane transport |
| nephron tubule morphogenesis |
| extrinsic component of membrane |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| renal tubule morphogenesis |
| cellular response to retinoic acid |
| negative regulation of ion transmembrane transporter activity |
| regulation of bone mineralization |
| nephron tubule development |
| negative regulation of transporter activity |
| renal tubule development |
| chondrocyte differentiation |
| negative regulation of cation transmembrane transport |
| metanephros development |
| kidney morphogenesis |
| positive regulation of ossification |
| ureteric bud development |
| mesonephric epithelium development |
| regulation of sodium ion transport |
| mesonephric tubule development |
| roof of mouth development |
| mesonephros development |
| regulation of biomineralization |
| regulation of biomineral tissue development |
| embryonic skeletal system morphogenesis |
| regulation of anion transport |
| negative regulation of ion transmembrane transport |
| segmentation |
| nephron epithelium development |
| regulation of response to drug |
| response to retinoic acid |
| negative regulation of transmembrane transport |
| ear morphogenesis |
| odontogenesis |
| embryonic epithelial tube formation |
| nephron development |
| mesoderm development |
| embryonic limb morphogenesis |
| embryonic appendage morphogenesis |
| embryonic skeletal system development |
| kidney epithelium development |
| regulation of embryonic development |
| epithelial tube formation |
| regulation of epithelial cell differentiation |
| morphogenesis of embryonic epithelium |
| negative regulation of ion transport |
| tube formation |
| appendage morphogenesis |
| limb morphogenesis |
| mesenchymal cell differentiation |
| stem cell differentiation |
| cartilage development |
| appendage development |
| limb development |
| positive regulation of epithelial cell proliferation |
| regulation of ossification |
| cellular response to acid chemical |
| gonad development |
| anterior/posterior pattern specification |
| development of primary sexual characteristics |
| mesenchyme development |
| ear development |
| connective tissue development |
| skeletal system morphogenesis |
| sensory organ morphogenesis |
| regulation of ion transmembrane transporter activity |
| regulation of transmembrane transporter activity |
| sex differentiation |
| kidney development |
| regulation of transporter activity |
| renal system development |
| embryonic organ morphogenesis |
| muscle tissue development |
| epithelial tube morphogenesis |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| urogenital system development |
| regionalization |
| regulation of cation transmembrane transport |
| regulation of epithelial cell proliferation |
| response to acid chemical |
| regulation of metal ion transport |
| reproductive structure development |
| reproductive system development |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| regulation of ion transmembrane transport |
| negative regulation of transport |
| blood vessel development |
| skeletal system development |
| vasculature development |
| cardiovascular system development |
| cellular response to lipid |
| heart development |
| sensory organ development |
| cell population proliferation |
| regulation of transmembrane transport |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| developmental process involved in reproduction |
| regulation of ion transport |
| negative regulation of cell differentiation |
| tube development |
| response to lipid |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| negative regulation of cell death |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Citral 75μM R06 exp275 | 1.77 |
| Azithromycin 100μM R08 exp452 | 1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15959
- Expression level (log2 read counts): -2.35
Expression Distribution
OSR1 Expression in NALM6 Cells: -2.35
