PASD1
Gene Information
- Official Symbol: PASD1
- Official Name: PAS domain containing repressor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 139135
- UniProt: Q8IV76
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a protein that is thought to function as a transcription factor. The protein is a cancer-associated antigen that can stimulate autologous T-cell responses, and it is therefore considered to be a potential immunotherapeutic target for the treatment of various hematopoietic malignancies, including diffuse large B-cell lymphoma. [provided by RefSeq, May 2010].
- UniProt Summary: Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK- ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). {ECO:0000269|PubMed:25936801}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13131
- Expression level (log2 read counts): -7.68
PASD1 Expression in NALM6 Cells: -7.68
