PAX2
Gene Information
- Official Symbol: PAX2
- Official Name: paired box 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5076
- UniProt: Q02962
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014].
- UniProt Summary: Transcription factor that may have a role in kidney cell differentiation (PubMed:24676634). Has a critical role in the development of the urogenital tract, the eyes, and the CNS. {ECO:0000269|PubMed:24676634}.
Pfam Domains GO Terms
Pfam Domains
| PAX |
| Pax2 C |
GO Terms
| optic chiasma development |
| positive regulation of optic nerve formation |
| regulation of optic nerve formation |
| regulation of metanephric DCT cell differentiation |
| negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis |
| positive regulation of metanephric DCT cell differentiation |
| regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis |
| pattern specification involved in pronephros development |
| negative regulation of apoptotic process involved in metanephric collecting duct development |
| regulation of apoptotic process involved in metanephric nephron tubule development |
| kidney field specification |
| optic nerve structural organization |
| regulation of apoptotic process involved in metanephric collecting duct development |
| negative regulation of apoptotic process involved in metanephric nephron tubule development |
| regulation of metanephros size |
| pronephric field specification |
| negative regulation of mesenchymal cell apoptotic process involved in metanephros development |
| kidney rudiment formation |
| regulation of mesenchymal cell apoptotic process involved in metanephros development |
| negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| retinal pigment epithelium development |
| regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis |
| metanephric nephron tubule formation |
| negative regulation of somatic stem cell population maintenance |
| positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| ureter maturation |
| metanephric mesenchymal cell differentiation |
| distal convoluted tubule development |
| negative regulation of cytolysis |
| vestibulocochlear nerve formation |
| nephric duct formation |
| regulation of kidney size |
| positive regulation of metanephric glomerulus development |
| metanephric distal convoluted tubule development |
| negative regulation of apoptotic process involved in development |
| metanephric tubule formation |
| regulation of metanephric glomerulus development |
| negative regulation of apoptotic process involved in morphogenesis |
| regulation of somatic stem cell population maintenance |
| optic nerve morphogenesis |
| negative regulation of stem cell population maintenance |
| metanephric distal tubule development |
| regulation of metanephric nephron tubule epithelial cell differentiation |
| mesenchymal to epithelial transition involved in metanephros morphogenesis |
| vestibulocochlear nerve morphogenesis |
| mesodermal cell fate specification |
| mesenchymal cell differentiation involved in renal system development |
| metanephric collecting duct development |
| positive regulation of epithelial cell differentiation involved in kidney development |
| mesenchymal cell differentiation involved in kidney development |
| metanephric nephron tubule morphogenesis |
| optic cup morphogenesis involved in camera-type eye development |
| regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| cranial nerve formation |
| negative regulation of metanephros development |
| pattern specification involved in kidney development |
| renal system pattern specification |
| pronephros development |
| vestibulocochlear nerve development |
| metanephric renal vesicle morphogenesis |
| negative regulation of mesenchymal cell apoptotic process |
| metanephric tubule morphogenesis |
| positive regulation of glomerulus development |
| cranial nerve structural organization |
| embryonic camera-type eye formation |
| regulation of apoptotic process involved in morphogenesis |
| distal tubule development |
| nephric duct morphogenesis |
| collecting duct development |
| regulation of apoptotic process involved in development |
| regulation of mesenchymal cell apoptotic process |
| renal vesicle morphogenesis |
| renal vesicle development |
| optic nerve development |
| regulation of nephron tubule epithelial cell differentiation |
| mesodermal cell fate commitment |
| metanephric mesenchyme development |
| positive regulation of metanephros development |
| mesenchymal to epithelial transition |
| metanephric nephron tubule development |
| ureter development |
| specification of animal organ identity |
| regulation of glomerulus development |
| negative regulation of kidney development |
| nephric duct development |
| anatomical structure arrangement |
| regulation of cytolysis |
| metanephric nephron epithelium development |
| nephron tubule formation |
| cell differentiation involved in metanephros development |
| positive regulation of branching involved in ureteric bud morphogenesis |
| kidney mesenchyme development |
| metanephric tubule development |
| regulation of epithelial cell differentiation involved in kidney development |
| metanephric nephron morphogenesis |
| positive regulation of mesonephros development |
| animal organ maturation |
| metanephric epithelium development |
| regulation of branching involved in ureteric bud morphogenesis |
| regulation of metanephros development |
| cochlea morphogenesis |
| regulation of mesonephros development |
| mesodermal cell differentiation |
| embryonic camera-type eye morphogenesis |
| metanephros morphogenesis |
| regulation of stem cell population maintenance |
| cell fate commitment involved in formation of primary germ layer |
| cranial nerve morphogenesis |
| centriolar satellite |
| epithelial cell differentiation involved in kidney development |
| metanephric nephron development |
| proximal promoter sequence-specific DNA binding |
| brain morphogenesis |
| negative regulation of animal organ morphogenesis |
| animal organ formation |
| positive regulation of morphogenesis of an epithelium |
| embryonic eye morphogenesis |
| embryonic camera-type eye development |
| protein kinase B signaling |
| cell fate determination |
| positive regulation of kidney development |
| cell differentiation involved in kidney development |
| cellular response to epidermal growth factor stimulus |
| branching involved in ureteric bud morphogenesis |
| protein-DNA complex |
| response to epidermal growth factor |
| cranial nerve development |
| cochlea development |
| ureteric bud morphogenesis |
| negative regulation of reactive oxygen species metabolic process |
| mesonephric tubule morphogenesis |
| regulation of kidney development |
| regulation of morphogenesis of a branching structure |
| positive regulation of epithelial cell differentiation |
| nephron tubule morphogenesis |
| nephron epithelium morphogenesis |
| nephron morphogenesis |
| mesoderm formation |
| renal tubule morphogenesis |
| mesoderm morphogenesis |
| cellular response to retinoic acid |
| cellular response to glucose stimulus |
| cellular response to hydrogen peroxide |
| cellular response to hexose stimulus |
| cellular response to monosaccharide stimulus |
| nephron tubule development |
| nerve development |
| renal tubule development |
| cellular response to carbohydrate stimulus |
| positive regulation of animal organ morphogenesis |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| metanephros development |
| kidney morphogenesis |
| ureteric bud development |
| mesonephric tubule development |
| mesonephric epithelium development |
| cellular glucose homeostasis |
| cell fate specification |
| negative regulation of cysteine-type endopeptidase activity |
| neural tube closure |
| mesonephros development |
| tube closure |
| nephron epithelium development |
| primary neural tube formation |
| inner ear morphogenesis |
| neural tube formation |
| response to retinoic acid |
| formation of primary germ layer |
| reactive oxygen species metabolic process |
| camera-type eye morphogenesis |
| cellular response to antibiotic |
| ear morphogenesis |
| response to hydrogen peroxide |
| embryonic epithelial tube formation |
| nephron development |
| mesoderm development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| cellular response to reactive oxygen species |
| epithelial tube formation |
| anatomical structure maturation |
| response to glucose |
| retina development in camera-type eye |
| regulation of epithelial cell differentiation |
| response to hexose |
| morphogenesis of embryonic epithelium |
| eye morphogenesis |
| tube formation |
| response to monosaccharide |
| mesenchymal cell differentiation |
| stem cell differentiation |
| microtubule organizing center |
| gastrulation |
| morphogenesis of a branching epithelium |
| neural tube development |
| morphogenesis of a branching structure |
| glial cell differentiation |
| response to carbohydrate |
| regulation of reactive oxygen species metabolic process |
| regulation of morphogenesis of an epithelium |
| glucose homeostasis |
| carbohydrate homeostasis |
| positive regulation of epithelial cell proliferation |
| inner ear development |
| response to reactive oxygen species |
| cellular response to acid chemical |
| cellular response to toxic substance |
| gliogenesis |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| transcription regulatory region DNA binding |
| ear development |
| mesenchyme development |
| visual perception |
| sensory perception of light stimulus |
| developmental maturation |
| cellular response to oxidative stress |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| cell fate commitment |
| lysosome |
| negative regulation of peptidase activity |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| kidney development |
| aging |
| renal system development |
| embryonic organ morphogenesis |
| response to antibiotic |
| epithelial tube morphogenesis |
| camera-type eye development |
| urogenital system development |
| transcription factor binding |
| regionalization |
| regulation of epithelial cell proliferation |
| response to acid chemical |
| negative regulation of proteolysis |
| eye development |
| visual system development |
| sensory system development |
| axonogenesis |
| response to oxidative stress |
| cellular response to drug |
| axon development |
| regulation of endopeptidase activity |
| morphogenesis of an epithelium |
| cell morphogenesis involved in neuron differentiation |
| embryonic organ development |
| pattern specification process |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| neuron projection morphogenesis |
| transcription by RNA polymerase II |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| response to nutrient levels |
| cellular response to growth factor stimulus |
| response to toxic substance |
| regulation of anatomical structure size |
| cell part morphogenesis |
| cellular response to lipid |
| response to growth factor |
| response to extracellular stimulus |
| response to inorganic substance |
| positive regulation of nervous system development |
| sensory organ development |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| protein-containing complex |
| chordate embryonic development |
| transcription, DNA-templated |
| nucleic acid-templated transcription |
| embryo development ending in birth or egg hatching |
| RNA biosynthetic process |
| tube morphogenesis |
| neuron projection development |
| DNA-binding transcription factor activity |
| epithelial cell differentiation |
| cell morphogenesis |
| regulation of proteolysis |
| brain development |
| cellular chemical homeostasis |
| head development |
| negative regulation of catalytic activity |
| neuron development |
| cellular component morphogenesis |
| tube development |
| response to lipid |
| nucleolus |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| cellular homeostasis |
| negative regulation of programmed cell death |
| positive regulation of cell population proliferation |
| regulation of nervous system development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| sensory perception |
| embryo development |
| central nervous system development |
| Golgi apparatus |
| negative regulation of cell death |
| neuron differentiation |
| response to drug |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| chemical homeostasis |
| epithelium development |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| cell projection organization |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| regulation of hydrolase activity |
| organic cyclic compound biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| neurogenesis |
| cellular nitrogen compound biosynthetic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| RNA metabolic process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| macromolecule biosynthetic process |
| regulation of cell differentiation |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Nicotinamide 2000μM R01 exp50 | -1.78 |
| Chloroquine 32μM R08 exp470 | 1.71 |
| Arsenic trioxide 60μM R08 exp449 | 2.11 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12521
- Expression level (log2 read counts): -4.6
Expression Distribution
PAX2 Expression in NALM6 Cells: -4.6
