PCGF3
Gene Information
- Official Symbol: PCGF3
- Official Name: polycomb group ring finger 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 10336
- UniProt: Q3KNV8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). {ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12424
- Expression level (log2 read counts): 6.8
PCGF3 Expression in NALM6 Cells: 6.8
