PDGFB
Gene Information
- Official Symbol: PDGFB
- Official Name: platelet derived growth factor subunit B
- Aliases and Previous Symbols: N/A
- Entrez ID: 5155
- UniProt: P01127
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit B, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit A. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Mutations in this gene are associated with meningioma. Reciprocal translocations between chromosomes 22 and 17, at sites where this gene and that for collagen type 1, alpha 1 are located, are associated with dermatofibrosarcoma protuberans, a rare skin tumor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015].
- UniProt Summary: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity). {ECO:0000250|UniProtKB:P31240, ECO:0000269|PubMed:26599395}.
Pfam Domains GO Terms
Pfam Domains
| PDGF N |
| PDGF |
GO Terms
| positive regulation of vascular smooth muscle cell dedifferentiation |
| metanephric glomerular mesangial cell development |
| response to mycophenolic acid |
| regulation of vascular smooth muscle cell dedifferentiation |
| negative regulation of phosphatidylinositol biosynthetic process |
| metanephric mesangial cell differentiation |
| metanephric glomerular mesangial cell differentiation |
| positive regulation of phenotypic switching |
| cellular response to mycophenolic acid |
| regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| positive regulation of metanephric mesenchymal cell migration |
| metanephric glomerular mesangium development |
| positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway |
| positive regulation of hyaluronan biosynthetic process |
| cellular response to mycotoxin |
| negative regulation of phospholipid biosynthetic process |
| regulation of metanephric mesenchymal cell migration |
| positive regulation of glomerular filtration |
| glomerular mesangial cell development |
| mesangial cell development |
| metanephric glomerulus vasculature development |
| positive regulation of glomerular mesangial cell proliferation |
| glomerular mesangial cell differentiation |
| regulation of phenotypic switching |
| cellular response to interleukin-18 |
| paracrine signaling |
| platelet-derived growth factor receptor-beta signaling pathway |
| interleukin-18-mediated signaling pathway |
| mesangial cell differentiation |
| response to mycotoxin |
| pericyte cell differentiation |
| glomerular mesangium development |
| regulation of hyaluronan biosynthetic process |
| negative regulation of vascular smooth muscle cell differentiation |
| positive regulation of cell proliferation involved in kidney development |
| regulation of phosphatidylinositol biosynthetic process |
| negative regulation of phospholipid metabolic process |
| response to interleukin-18 |
| regulation of glomerular mesangial cell proliferation |
| superoxide-generating NADPH oxidase activator activity |
| metanephric glomerulus development |
| positive regulation of glomerulus development |
| regulation of glomerular filtration |
| platelet-derived growth factor binding |
| negative regulation of pri-miRNA transcription by RNA polymerase II |
| regulation of cell proliferation involved in kidney development |
| protein kinase C signaling |
| positive regulation of metanephros development |
| regulation of vascular smooth muscle cell differentiation |
| platelet-derived growth factor receptor binding |
| regulation of glomerulus development |
| renal system process involved in regulation of blood volume |
| positive regulation of vascular associated smooth muscle cell migration |
| negative regulation of smooth muscle cell differentiation |
| regulation of phospholipid biosynthetic process |
| cell differentiation involved in metanephros development |
| glomerulus vasculature development |
| negative regulation of platelet activation |
| positive regulation of calcium ion import |
| renal system vasculature development |
| kidney vasculature development |
| regulation of vascular associated smooth muscle cell migration |
| regulation of metanephros development |
| renal system process involved in regulation of systemic arterial blood pressure |
| positive regulation of protein autophosphorylation |
| epithelial cell differentiation involved in kidney development |
| regulation of platelet activation |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| regulation of smooth muscle cell differentiation |
| positive regulation of pri-miRNA transcription by RNA polymerase II |
| metanephric nephron development |
| activation of protein kinase B activity |
| positive regulation of phosphatidylinositol 3-kinase activity |
| positive regulation of vascular smooth muscle cell proliferation |
| platelet-derived growth factor receptor signaling pathway |
| positive regulation of cyclin-dependent protein kinase activity |
| regulation of renal system process |
| chemoattractant activity |
| positive regulation of lipid kinase activity |
| positive regulation of smooth muscle cell migration |
| regulation of polysaccharide biosynthetic process |
| regulation of calcium ion import |
| positive regulation of kidney development |
| cell differentiation involved in kidney development |
| regulation of pri-miRNA transcription by RNA polymerase II |
| regulation of polysaccharide metabolic process |
| monocyte chemotaxis |
| regulation of protein autophosphorylation |
| positive regulation of phospholipid metabolic process |
| positive chemotaxis |
| mononuclear cell migration |
| negative regulation of lipid biosynthetic process |
| regulation of vascular smooth muscle cell proliferation |
| positive regulation of fibroblast proliferation |
| negative regulation of blood coagulation |
| glomerulus development |
| negative regulation of hemostasis |
| negative regulation of coagulation |
| regulation of phosphatidylinositol 3-kinase activity |
| positive regulation of mitotic nuclear division |
| regulation of kidney development |
| positive regulation of blood vessel endothelial cell migration |
| negative regulation of muscle cell differentiation |
| positive regulation of protein tyrosine kinase activity |
| regulation of smooth muscle cell migration |
| regulation of lipid kinase activity |
| collagen binding |
| positive regulation of nuclear division |
| positive regulation of DNA biosynthetic process |
| platelet alpha granule lumen |
| negative regulation of wound healing |
| regulation of blood coagulation |
| positive regulation of carbohydrate metabolic process |
| regulation of hemostasis |
| regulation of fibroblast proliferation |
| regulation of coagulation |
| negative regulation of lipid metabolic process |
| metanephros development |
| regulation of phospholipid metabolic process |
| positive regulation of smooth muscle cell proliferation |
| negative regulation of response to wounding |
| positive regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of cell division |
| embryonic placenta development |
| regulation of protein tyrosine kinase activity |
| regulation of blood vessel endothelial cell migration |
| positive regulation of endothelial cell proliferation |
| regulation of systemic arterial blood pressure |
| regulation of carbohydrate biosynthetic process |
| response to antineoplastic agent |
| positive regulation of reactive oxygen species metabolic process |
| positive regulation of endothelial cell migration |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| Golgi lumen |
| negative regulation of protein binding |
| regulation of cyclin-dependent protein kinase activity |
| renal system process |
| reactive oxygen species metabolic process |
| regulation of DNA biosynthetic process |
| negative regulation of vasculature development |
| cellular response to antibiotic |
| regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of calcium ion transport |
| nephron development |
| myeloid leukocyte migration |
| platelet degranulation |
| regulation of endothelial cell proliferation |
| regulation of smooth muscle cell proliferation |
| positive regulation of chemotaxis |
| regulation of wound healing |
| positive regulation of small molecule metabolic process |
| positive regulation of epithelial cell migration |
| positive regulation of lipid metabolic process |
| peptidyl-tyrosine phosphorylation |
| leukocyte chemotaxis |
| peptidyl-tyrosine modification |
| positive regulation of mitotic cell cycle |
| placenta development |
| regulation of muscle cell differentiation |
| regulation of endothelial cell migration |
| growth factor activity |
| positive regulation of protein kinase B signaling |
| regulation of response to wounding |
| regulation of mitotic nuclear division |
| regulation of cell division |
| negative regulation of binding |
| peptidyl-serine phosphorylation |
| regulation of reactive oxygen species metabolic process |
| regulation of blood pressure |
| positive regulation of vasculature development |
| cellular response to xenobiotic stimulus |
| regulation of lipid biosynthetic process |
| positive regulation of epithelial cell proliferation |
| positive regulation of peptidyl-tyrosine phosphorylation |
| regulation of nuclear division |
| epithelial cell development |
| positive regulation of DNA metabolic process |
| negative regulation of cell activation |
| basolateral plasma membrane |
| peptidyl-serine modification |
| regulation of carbohydrate metabolic process |
| cellular response to acid chemical |
| cell chemotaxis |
| positive regulation of ERK1 and ERK2 cascade |
| regulation of chemotaxis |
| cellular response to toxic substance |
| regulation of protein binding |
| regulation of protein kinase B signaling |
| regulation of epithelial cell migration |
| connective tissue development |
| regulation of calcium ion transport |
| regulation of peptidyl-tyrosine phosphorylation |
| positive regulation of MAP kinase activity |
| kidney development |
| positive regulation of ion transport |
| renal system development |
| positive regulation of cell cycle process |
| regulation of ERK1 and ERK2 cascade |
| response to xenobiotic stimulus |
| endoplasmic reticulum lumen |
| response to antibiotic |
| urogenital system development |
| regulation of vasculature development |
| activation of protein kinase activity |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| extracellular matrix organization |
| regulation of MAP kinase activity |
| response to acid chemical |
| regulation of DNA metabolic process |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| MAPK cascade |
| in utero embryonic development |
| regulation of binding |
| positive regulation of cell cycle |
| leukocyte migration |
| extracellular structure organization |
| regulation of metal ion transport |
| blood circulation |
| signal transduction by protein phosphorylation |
| circulatory system process |
| regulation of lipid metabolic process |
| cellular response to drug |
| reproductive structure development |
| regulation of small molecule metabolic process |
| reproductive system development |
| embryonic organ development |
| blood vessel development |
| protein heterodimerization activity |
| regulation of body fluid levels |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| response to toxic substance |
| vasculature development |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of cellular component movement |
| cellular response to organic cyclic compound |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| response to wounding |
| positive regulation of kinase activity |
| regulation of system process |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| cell surface |
| Golgi membrane |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| chordate embryonic development |
| regulation of cell activation |
| immune system development |
| embryo development ending in birth or egg hatching |
| positive regulation of transferase activity |
| developmental process involved in reproduction |
| cytokine-mediated signaling pathway |
| epithelial cell differentiation |
| regulation of ion transport |
| regulated exocytosis |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| exocytosis |
| regulation of protein kinase activity |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| regulation of kinase activity |
| protein homodimerization activity |
| peptidyl-amino acid modification |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| negative regulation of developmental process |
| cell migration |
| protein phosphorylation |
| regulation of transferase activity |
| embryo development |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| secretion by cell |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| export from cell |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| identical protein binding |
| cell motility |
| localization of cell |
| regulation of response to external stimulus |
| response to cytokine |
| epithelium development |
| cell-cell signaling |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| regulation of organelle organization |
| locomotion |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9086
- Expression level (log2 read counts): -3.35
Expression Distribution
PDGFB Expression in NALM6 Cells: -3.35
