PECAM1
Gene Information
- Official Symbol: PECAM1
- Official Name: platelet and endothelial cell adhesion molecule 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 5175
- UniProt: P16284
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| endothelial cell-matrix adhesion |
| glomerular endothelium development |
| smooth muscle contractile fiber |
| monocyte extravasation |
| neutrophil extravasation |
| diapedesis |
| endothelial cell morphogenesis |
| platelet alpha granule membrane |
| glomerulus vasculature development |
| glomerular epithelium development |
| kidney vasculature development |
| renal system vasculature development |
| cell-cell contact zone |
| epithelial cell morphogenesis |
| bicellular tight junction assembly |
| tight junction assembly |
| cellular extravasation |
| tight junction organization |
| apical junction assembly |
| mononuclear cell migration |
| endothelial cell development |
| leukocyte cell-cell adhesion |
| glomerulus development |
| endothelial cell migration |
| positive regulation of tyrosine phosphorylation of STAT protein |
| Rho protein signal transduction |
| regulation of tyrosine phosphorylation of STAT protein |
| endothelial cell differentiation |
| epithelial cell migration |
| positive regulation of receptor signaling pathway via JAK-STAT |
| epithelium migration |
| positive regulation of receptor signaling pathway via STAT |
| neutrophil migration |
| tissue migration |
| endothelium development |
| nephron epithelium development |
| secretory granule membrane |
| granulocyte migration |
| cell-cell junction assembly |
| nephron development |
| cell-matrix adhesion |
| myeloid leukocyte migration |
| kidney epithelium development |
| platelet degranulation |
| regulation of receptor signaling pathway via JAK-STAT |
| regulation of receptor signaling pathway via STAT |
| cell-cell junction organization |
| cell junction assembly |
| homophilic cell adhesion via plasma membrane adhesion molecules |
| ameboidal-type cell migration |
| cell-cell junction |
| cell-substrate adhesion |
| positive regulation of peptidyl-tyrosine phosphorylation |
| epithelial cell development |
| cell junction organization |
| membrane raft |
| cell recognition |
| Ras protein signal transduction |
| regulation of peptidyl-tyrosine phosphorylation |
| cell-cell adhesion via plasma-membrane adhesion molecules |
| kidney development |
| renal system development |
| angiogenesis |
| urogenital system development |
| small GTPase mediated signal transduction |
| phagocytosis |
| extracellular matrix organization |
| leukocyte migration |
| extracellular structure organization |
| external side of plasma membrane |
| blood vessel morphogenesis |
| wound healing |
| blood vessel development |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| cell-cell adhesion |
| vasculature development |
| leukocyte degranulation |
| cardiovascular system development |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| positive regulation of cell motility |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| cell morphogenesis involved in differentiation |
| response to wounding |
| myeloid leukocyte activation |
| protein-containing complex |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| tube morphogenesis |
| epithelial cell differentiation |
| regulated exocytosis |
| cell morphogenesis |
| leukocyte mediated immunity |
| exocytosis |
| cellular component morphogenesis |
| tube development |
| regulation of cell migration |
| circulatory system development |
| protein homodimerization activity |
| anatomical structure formation involved in morphogenesis |
| regulation of cell motility |
| leukocyte activation |
| cell adhesion |
| biological adhesion |
| cell migration |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| positive regulation of protein phosphorylation |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| localization of cell |
| cell motility |
| immune effector process |
| epithelium development |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of protein modification process |
| locomotion |
| regulation of protein phosphorylation |
| movement of cell or subcellular component |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| cell development |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| immune response |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: N/A
| Tissue | Fraction Of Cell Lines Where Essential |
|---|
Essentiality in NALM6
- Essentiality Rank: 11527
- Expression level (log2 read counts): 2.86
Expression Distribution
PECAM1 Expression in NALM6 Cells: 2.86
