PHLDA2
Gene Information
- Official Symbol: PHLDA2
- Official Name: pleckstrin homology like domain family A member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 7262
- UniProt: Q53GA4
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is located in a cluster of imprinted genes on chromosome 11p15.5, which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene has been shown to be imprinted, with preferential expression from the maternal allele in placenta and liver. [provided by RefSeq, Oct 2010].
- UniProt Summary: Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids (By similarity). {ECO:0000250}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13855
- Expression level (log2 read counts): -4.6
PHLDA2 Expression in NALM6 Cells: -4.6
