PHLDB2
Gene Information
- Official Symbol: PHLDB2
- Official Name: pleckstrin homology like domain family B member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 90102
- UniProt: Q86SQ0
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
Pfam Domains GO Terms
Pfam Domains
| PH |
GO Terms
| negative regulation of wound healing, spreading of epidermal cells |
| regulation of basement membrane assembly involved in embryonic body morphogenesis |
| regulation of basement membrane organization |
| basal cortex |
| positive regulation of basement membrane assembly involved in embryonic body morphogenesis |
| regulation of wound healing, spreading of epidermal cells |
| negative regulation of morphogenesis of an epithelium |
| negative regulation of focal adhesion assembly |
| negative regulation of adherens junction organization |
| negative regulation of stress fiber assembly |
| positive regulation of extracellular matrix organization |
| negative regulation of cell junction assembly |
| negative regulation of actin filament bundle assembly |
| positive regulation of embryonic development |
| regulation of gastrulation |
| negative regulation of cell-matrix adhesion |
| regulation of extracellular matrix organization |
| cell leading edge |
| intermediate filament cytoskeleton |
| regulation of cell-substrate junction assembly |
| regulation of focal adhesion assembly |
| negative regulation of cell-substrate adhesion |
| regulation of adherens junction organization |
| negative regulation of wound healing |
| regulation of stress fiber assembly |
| regulation of epithelial to mesenchymal transition |
| negative regulation of response to wounding |
| regulation of cell junction assembly |
| regulation of actomyosin structure organization |
| regulation of actin filament bundle assembly |
| regulation of cell-matrix adhesion |
| regulation of embryonic development |
| negative regulation of supramolecular fiber organization |
| regulation of wound healing |
| negative regulation of cytoskeleton organization |
| regulation of response to wounding |
| regulation of morphogenesis of an epithelium |
| regulation of microtubule cytoskeleton organization |
| regulation of cell-substrate adhesion |
| regulation of microtubule-based process |
| negative regulation of cell migration |
| regulation of actin filament organization |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| negative regulation of cellular component movement |
| cadherin binding |
| negative regulation of locomotion |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| negative regulation of response to external stimulus |
| negative regulation of organelle organization |
| regulation of actin filament-based process |
| focal adhesion |
| microtubule cytoskeleton organization |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| microtubule-based process |
| regulation of cell adhesion |
| negative regulation of cellular component organization |
| regulation of cell migration |
| regulation of cell motility |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| regulation of locomotion |
| regulation of cellular component movement |
| regulation of anatomical structure morphogenesis |
| regulation of response to external stimulus |
| cytoskeleton organization |
| positive regulation of cellular component organization |
| regulation of organelle organization |
| positive regulation of developmental process |
| regulation of response to stress |
| establishment of protein localization |
| negative regulation of response to stimulus |
| positive regulation of multicellular organismal process |
| regulation of cell differentiation |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 5514
- Expression level (log2 read counts): 5.03
Expression Distribution
PHLDB2 Expression in NALM6 Cells: 5.03
