PIEZO2

• Official Symbol: PIEZO2
• Official Name: piezo type mechanosensitive ion channel component 2
• Aliases and Previous Symbols: N/A
• Entrez ID: 63895
• UniProt: Q9H5I5
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: Open OMIM

• Entrez Summary: The protein encoded by this gene contains more than thirty transmembrane domains and likely functions as part of mechanically-activated (MA) cation channels. These channels serve to connect mechanical forces to biological signals. The encoded protein quickly adapts MA currents in somatosensory neurons. Defects in this gene are a cause of type 5 distal arthrogryposis. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014].
• UniProt Summary: Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light- touch mechanosensation. {ECO:0000250|UniProtKB:Q8CD54}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 18975
• Expression level (log2 read counts): -0.32

Expression Distribution

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PIEZO2 Expression in NALM6 Cells: -0.32