PIWIL2
Gene Information
- Official Symbol: PIWIL2
- Official Name: piwi like RNA-mediated gene silencing 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 55124
- UniProt: Q8TC59
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Piwi |
| PAZ |
GO Terms
| perinucleolar chromocenter |
| PET complex |
| germ-line stem cell population maintenance |
| piRNA binding |
| positive regulation of histone H3-K14 acetylation |
| positive regulation of meiosis I |
| piRNA biosynthetic process |
| polysome binding |
| regulation of histone H3-K14 acetylation |
| dense body |
| pi-body |
| regulation of meiosis I |
| positive regulation of histone H3-K9 acetylation |
| chromatoid body |
| regulation of histone H3-K9 acetylation |
| positive regulation of meiotic nuclear division |
| negative regulation of circadian rhythm |
| P granule |
| piRNA metabolic process |
| DNA methylation involved in gamete generation |
| RNA 5-end processing |
| negative regulation of transposition |
| regulation of transposition |
| positive regulation of meiotic cell cycle |
| endoribonuclease activity |
| positive regulation of histone acetylation |
| regulation of meiotic nuclear division |
| positive regulation of peptidyl-lysine acetylation |
| positive regulation of protein acetylation |
| DNA alkylation |
| DNA methylation |
| regulation of meiotic cell cycle |
| regulation of histone acetylation |
| regulation of peptidyl-lysine acetylation |
| DNA methylation or demethylation |
| positive regulation of nuclear division |
| regulation of protein acetylation |
| oogenesis |
| positive regulation of reproductive process |
| RNA phosphodiester bond hydrolysis, endonucleolytic |
| gene silencing by RNA |
| DNA modification |
| positive regulation of histone modification |
| positive regulation of chromatin organization |
| regulation of circadian rhythm |
| positive regulation of translation |
| female gamete generation |
| stem cell population maintenance |
| maintenance of cell number |
| regulation of histone modification |
| positive regulation of cellular amide metabolic process |
| gene silencing |
| RNA phosphodiester bond hydrolysis |
| regulation of reproductive process |
| mRNA binding |
| positive regulation of chromosome organization |
| regulation of chromatin organization |
| regulation of nuclear division |
| meiotic cell cycle |
| macromolecule methylation |
| germ cell development |
| rhythmic process |
| positive regulation of cell cycle process |
| nucleic acid phosphodiester bond hydrolysis |
| methylation |
| regulation of chromosome organization |
| regulation of translation |
| cellular process involved in reproduction in multicellular organism |
| positive regulation of cell cycle |
| regulation of cellular amide metabolic process |
| ncRNA metabolic process |
| posttranscriptional regulation of gene expression |
| spermatogenesis |
| male gamete generation |
| positive regulation of organelle organization |
| developmental process involved in reproduction |
| gamete generation |
| DNA metabolic process |
| regulation of cell cycle process |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| RNA processing |
| multi-organism reproductive process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| positive regulation of protein modification process |
| regulation of organelle organization |
| cell cycle |
| reproductive process |
| reproduction |
| positive regulation of cellular protein metabolic process |
| cell development |
| RNA metabolic process |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| regulation of protein modification process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mubritinib 0.2μM R01 exp48 | -2.49 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6378
- Expression level (log2 read counts): 1.75
Expression Distribution
PIWIL2 Expression in NALM6 Cells: 1.75
