PKIA
Gene Information
- Official Symbol: PKIA
- Official Name: cAMP-dependent protein kinase inhibitor alpha
- Aliases and Previous Symbols: N/A
- Entrez ID: 5569
- UniProt: P61925
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
Pfam Domains GO Terms
Pfam Domains
| PKI |
GO Terms
| cAMP-dependent protein kinase inhibitor activity |
| negative regulation of cAMP-dependent protein kinase activity |
| negative regulation of protein import into nucleus |
| negative regulation of protein import |
| protein kinase A catalytic subunit binding |
| regulation of cAMP-dependent protein kinase activity |
| negative regulation of nucleocytoplasmic transport |
| negative regulation of protein localization to nucleus |
| negative regulation of intracellular protein transport |
| regulation of protein import into nucleus |
| regulation of protein import |
| negative regulation of intracellular transport |
| regulation of nucleocytoplasmic transport |
| negative regulation of cellular protein localization |
| regulation of protein localization to nucleus |
| negative regulation of protein serine/threonine kinase activity |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| regulation of G2/M transition of mitotic cell cycle |
| regulation of cell cycle G2/M phase transition |
| negative regulation of protein kinase activity |
| regulation of intracellular protein transport |
| negative regulation of kinase activity |
| negative regulation of transferase activity |
| regulation of intracellular transport |
| negative regulation of protein phosphorylation |
| regulation of mitotic cell cycle phase transition |
| negative regulation of phosphorylation |
| regulation of cell cycle phase transition |
| negative regulation of transport |
| regulation of protein serine/threonine kinase activity |
| regulation of cellular protein localization |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| regulation of mitotic cell cycle |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of cell cycle process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| negative regulation of transcription by RNA polymerase II |
| regulation of kinase activity |
| regulation of cellular localization |
| regulation of transferase activity |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| regulation of phosphorylation |
| negative regulation of gene expression |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| PU-H71 1μM R08 exp515 | 1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18309
- Expression level (log2 read counts): -3.8
Expression Distribution
PKIA Expression in NALM6 Cells: -3.8
