PLEK
Gene Information
- Official Symbol: PLEK
- Official Name: pleckstrin
- Aliases and Previous Symbols: N/A
- Entrez ID: 5341
- UniProt: P08567
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Major protein kinase C substrate of platelets.
Pfam Domains GO Terms
Pfam Domains
| DEP |
| PH |
GO Terms
| positive regulation of inositol-polyphosphate 5-phosphatase activity |
| phospholipase C-inhibiting G protein-coupled receptor signaling pathway |
| negative regulation of inositol phosphate biosynthetic process |
| regulation of cell diameter |
| regulation of inositol-polyphosphate 5-phosphatase activity |
| protein secretion by platelet |
| positive regulation of platelet activation |
| positive regulation of integrin activation |
| thrombin-activated receptor signaling pathway |
| regulation of integrin activation |
| negative regulation of alcohol biosynthetic process |
| positive regulation of actin filament depolymerization |
| protein kinase C signaling |
| regulation of inositol phosphate biosynthetic process |
| positive regulation of protein depolymerization |
| ruffle organization |
| positive regulation of blood coagulation |
| positive regulation of hemostasis |
| positive regulation of coagulation |
| negative regulation of calcium-mediated signaling |
| phosphatidylinositol-3,4-bisphosphate binding |
| regulation of platelet activation |
| positive regulation of phosphatase activity |
| positive regulation of protein complex disassembly |
| vesicle docking involved in exocytosis |
| cortical actin cytoskeleton organization |
| negative regulation of cellular carbohydrate metabolic process |
| platelet aggregation |
| cortical cytoskeleton organization |
| negative regulation of G protein-coupled receptor signaling pathway |
| negative regulation of carbohydrate metabolic process |
| regulation of actin filament depolymerization |
| protein kinase C binding |
| positive regulation of wound healing |
| positive regulation of dephosphorylation |
| homotypic cell-cell adhesion |
| positive regulation of actin filament bundle assembly |
| vesicle docking |
| positive regulation of response to wounding |
| actin cytoskeleton reorganization |
| exocytic process |
| regulation of alcohol biosynthetic process |
| regulation of blood coagulation |
| regulation of hemostasis |
| regulation of coagulation |
| regulation of protein depolymerization |
| hematopoietic progenitor cell differentiation |
| negative regulation of small molecule metabolic process |
| regulation of actin filament bundle assembly |
| integrin-mediated signaling pathway |
| regulation of carbohydrate biosynthetic process |
| ruffle membrane |
| regulation of calcium-mediated signaling |
| regulation of protein complex disassembly |
| platelet degranulation |
| platelet activation |
| regulation of wound healing |
| regulation of cellular carbohydrate metabolic process |
| regulation of G protein-coupled receptor signaling pathway |
| protein secretion |
| establishment of protein localization to extracellular region |
| protein localization to extracellular region |
| regulation of response to wounding |
| phosphatidylinositol metabolic process |
| organelle localization by membrane tethering |
| peptide secretion |
| regulation of phosphatase activity |
| membrane docking |
| regulation of cell size |
| regulation of actin polymerization or depolymerization |
| regulation of actin filament length |
| positive regulation of supramolecular fiber organization |
| regulation of carbohydrate metabolic process |
| regulation of dephosphorylation |
| positive regulation of cytoskeleton organization |
| positive regulation of protein complex assembly |
| regulation of actin filament organization |
| blood coagulation |
| coagulation |
| hemostasis |
| glycerophospholipid metabolic process |
| regulation of actin cytoskeleton organization |
| regulation of supramolecular fiber organization |
| phospholipid metabolic process |
| regulation of cellular component size |
| glycerolipid metabolic process |
| regulation of actin filament-based process |
| positive regulation of cell activation |
| regulation of small molecule metabolic process |
| regulation of protein complex assembly |
| wound healing |
| actin cytoskeleton organization |
| regulation of body fluid levels |
| cell-cell adhesion |
| negative regulation of intracellular signal transduction |
| regulation of anatomical structure size |
| positive regulation of cellular component biogenesis |
| regulation of cytoskeleton organization |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| actin filament-based process |
| response to wounding |
| organelle localization |
| hematopoietic or lymphoid organ development |
| positive regulation of organelle organization |
| regulation of cell activation |
| immune system development |
| regulated exocytosis |
| positive regulation of hydrolase activity |
| exocytosis |
| protein homodimerization activity |
| organophosphate metabolic process |
| cell adhesion |
| biological adhesion |
| cellular lipid metabolic process |
| regulation of cellular component biogenesis |
| secretion by cell |
| export from cell |
| cell activation |
| regulation of response to external stimulus |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| secretion |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| positive regulation of cellular component organization |
| lipid metabolic process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| regulation of organelle organization |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of response to stress |
| protein transport |
| negative regulation of cellular biosynthetic process |
| peptide transport |
| negative regulation of biosynthetic process |
| amide transport |
| establishment of protein localization |
| negative regulation of response to stimulus |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of intracellular signal transduction |
| nitrogen compound transport |
| extracellular region |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9485
- Expression level (log2 read counts): -1.17
Expression Distribution
PLEK Expression in NALM6 Cells: -1.17
