POGZ
Gene Information
- Official Symbol: POGZ
- Official Name: pogo transposable element derived with ZNF domain
- Aliases and Previous Symbols: N/A
- Entrez ID: 23126
- UniProt: Q7Z3K3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010].
- UniProt Summary: Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. {ECO:0000269|PubMed:20562864}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4126
- Expression level (log2 read counts): 7.21
POGZ Expression in NALM6 Cells: 7.21
