POSTN
Gene Information
- Official Symbol: POSTN
- Official Name: periostin
- Aliases and Previous Symbols: N/A
- Entrez ID: 10631
- UniProt: Q15063
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Fasciclin |
GO Terms
| cellular response to vitamin K |
| positive regulation of chemokine (C-C motif) ligand 2 secretion |
| regulation of chemokine (C-C motif) ligand 2 secretion |
| bone regeneration |
| response to vitamin K |
| positive regulation of chemokine (C-X-C motif) ligand 2 production |
| regulation of chemokine (C-X-C motif) ligand 2 production |
| negative regulation of substrate adhesion-dependent cell spreading |
| positive regulation of chemokine secretion |
| regulation of chemokine secretion |
| response to muscle activity |
| cellular response to vitamin |
| positive regulation of smooth muscle cell migration |
| negative regulation of cell-matrix adhesion |
| regulation of substrate adhesion-dependent cell spreading |
| positive regulation of chemokine production |
| cell adhesion molecule binding |
| neuron projection extension |
| regulation of smooth muscle cell migration |
| negative regulation of cell-substrate adhesion |
| tissue regeneration |
| response to activity |
| cellular response to nutrient |
| neuromuscular junction |
| regulation of chemokine production |
| response to vitamin |
| developmental cell growth |
| cell growth |
| regulation of systemic arterial blood pressure |
| negative regulation of cell morphogenesis involved in differentiation |
| regulation of Notch signaling pathway |
| cellular response to fibroblast growth factor stimulus |
| developmental growth involved in morphogenesis |
| regulation of cell-matrix adhesion |
| response to fibroblast growth factor |
| extracellular matrix structural constituent |
| response to estradiol |
| positive regulation of cytokine secretion |
| cellular response to transforming growth factor beta stimulus |
| regeneration |
| response to transforming growth factor beta |
| trans-Golgi network |
| heparin binding |
| regulation of blood pressure |
| regulation of cytokine secretion |
| regulation of cell-substrate adhesion |
| response to mechanical stimulus |
| response to nutrient |
| extracellular matrix |
| cellular response to nutrient levels |
| cellular response to tumor necrosis factor |
| response to tumor necrosis factor |
| cellular response to extracellular stimulus |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| positive regulation of peptide secretion |
| regulation of cell morphogenesis involved in differentiation |
| negative regulation of cell development |
| cellular response to external stimulus |
| extracellular matrix organization |
| response to hypoxia |
| response to decreased oxygen levels |
| collagen-containing extracellular matrix |
| response to oxygen levels |
| extracellular structure organization |
| developmental growth |
| blood circulation |
| growth |
| circulatory system process |
| positive regulation of secretion by cell |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| wound healing |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of peptide secretion |
| response to nutrient levels |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| cell part morphogenesis |
| positive regulation of cell motility |
| response to growth factor |
| response to extracellular stimulus |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| response to wounding |
| neuron projection development |
| regulation of cell adhesion |
| regulation of cytokine production |
| negative regulation of cellular component organization |
| regulation of protein transport |
| negative regulation of cell differentiation |
| cell morphogenesis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| regulation of cell migration |
| response to lipid |
| response to hormone |
| regulation of cell motility |
| response to organic cyclic compound |
| cell adhesion |
| regulation of cell development |
| biological adhesion |
| negative regulation of developmental process |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cellular response to cytokine stimulus |
| neuron differentiation |
| regulation of protein localization |
| regulation of anatomical structure morphogenesis |
| response to cytokine |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| response to abiotic stimulus |
| cellular response to endogenous stimulus |
| response to endogenous stimulus |
| generation of neurons |
| response to oxygen-containing compound |
| extracellular space |
| neurogenesis |
| cell development |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of cell differentiation |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Q15 2.7μM R02 exp79 | 2.33 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 7445
- Expression level (log2 read counts): -5.6
Expression Distribution
POSTN Expression in NALM6 Cells: -5.6
