PPAT
Gene Information
- Official Symbol: PPAT
- Official Name: phosphoribosyl pyrophosphate amidotransferase
- Aliases and Previous Symbols: N/A
- Entrez ID: 5471
- UniProt: Q06203
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pribosyltran |
| GATase 2 |
GO Terms
| amidophosphoribosyltransferase activity |
| glutamine catabolic process |
| de novo IMP biosynthetic process |
| IMP biosynthetic process |
| purine nucleobase biosynthetic process |
| IMP metabolic process |
| purine ribonucleoside monophosphate biosynthetic process |
| purine nucleoside monophosphate biosynthetic process |
| nucleobase biosynthetic process |
| purine nucleobase metabolic process |
| glutamine metabolic process |
| glutamine family amino acid catabolic process |
| ribonucleoside monophosphate biosynthetic process |
| purine ribonucleoside monophosphate metabolic process |
| purine nucleoside monophosphate metabolic process |
| 4 iron, 4 sulfur cluster binding |
| nucleobase metabolic process |
| nucleoside monophosphate biosynthetic process |
| lactation |
| pigment biosynthetic process |
| ribonucleoside monophosphate metabolic process |
| maternal process involved in female pregnancy |
| pigment metabolic process |
| glutamine family amino acid metabolic process |
| animal organ regeneration |
| body fluid secretion |
| nucleoside monophosphate metabolic process |
| protein homotetramerization |
| alpha-amino acid catabolic process |
| nucleoside metabolic process |
| G1/S transition of mitotic cell cycle |
| cell cycle G1/S phase transition |
| cellular amino acid catabolic process |
| mammary gland development |
| glycosyl compound metabolic process |
| purine ribonucleotide biosynthetic process |
| protein tetramerization |
| regeneration |
| purine nucleotide biosynthetic process |
| ribonucleotide biosynthetic process |
| cellular response to insulin stimulus |
| ribose phosphate biosynthetic process |
| purine-containing compound biosynthetic process |
| female pregnancy |
| alpha-amino acid metabolic process |
| multi-multicellular organism process |
| response to insulin |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| cellular response to peptide hormone stimulus |
| organic acid catabolic process |
| carboxylic acid catabolic process |
| kidney development |
| mitotic cell cycle phase transition |
| cell cycle phase transition |
| renal system development |
| cellular amino acid metabolic process |
| purine ribonucleotide metabolic process |
| urogenital system development |
| cellular response to peptide |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| protein homooligomerization |
| purine-containing compound metabolic process |
| response to peptide hormone |
| cellular response to drug |
| gland development |
| small molecule catabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| response to peptide |
| regulation of body fluid levels |
| protein complex oligomerization |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| mitotic cell cycle process |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| carbohydrate derivative biosynthetic process |
| cellular response to nitrogen compound |
| mitotic cell cycle |
| multicellular organismal reproductive process |
| multicellular organism reproduction |
| organophosphate metabolic process |
| response to hormone |
| carboxylic acid metabolic process |
| multi-organism reproductive process |
| cell cycle process |
| response to organonitrogen compound |
| oxoacid metabolic process |
| response to drug |
| organic acid metabolic process |
| carbohydrate derivative metabolic process |
| cellular response to oxygen-containing compound |
| organonitrogen compound catabolic process |
| response to nitrogen compound |
| nucleobase-containing compound biosynthetic process |
| secretion |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| cellular response to endogenous stimulus |
| organic cyclic compound biosynthetic process |
| cell cycle |
| organonitrogen compound biosynthetic process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| cellular nitrogen compound biosynthetic process |
| small molecule metabolic process |
| organic substance catabolic process |
| cellular catabolic process |
| protein-containing complex subunit organization |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 72/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 3/28 |
| blood | 9/28 |
| bone | 1/26 |
| breast | 5/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 2/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 3/21 |
| liver | 0/20 |
| lung | 12/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 5/24 |
| peripheral nervous system | 1/16 |
| plasma cell | 4/15 |
| prostate | 0/1 |
| skin | 1/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 5/29 |
| uterus | 1/5 |
Essentiality in NALM6
- Essentiality Rank: 1181
- Expression level (log2 read counts): 6.67
Expression Distribution
PPAT Expression in NALM6 Cells: 6.67
