PPP1R3C
Gene Information
- Official Symbol: PPP1R3C
- Official Name: protein phosphatase 1 regulatory subunit 3C
- Aliases and Previous Symbols: N/A
- Entrez ID: 5507
- UniProt: Q9UQK1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016].
- UniProt Summary: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:8985175}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 16669
- Expression level (log2 read counts): -7.68
PPP1R3C Expression in NALM6 Cells: -7.68
