PPP3CB
Gene Information
- Official Symbol: PPP3CB
- Official Name: protein phosphatase 3 catalytic subunit beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 5532
- UniProt: P16298
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.
Pfam Domains GO Terms
Pfam Domains
| Metallophos |
GO Terms
| calmodulin-dependent protein phosphatase activity |
| calcineurin complex |
| locomotion involved in locomotory behavior |
| protein phosphatase 2B binding |
| negative regulation of T cell mediated cytotoxicity |
| lymphangiogenesis |
| calcineurin-NFAT signaling cascade |
| lymph vessel morphogenesis |
| calcineurin-mediated signaling |
| regulation of synaptic vesicle endocytosis |
| negative regulation of leukocyte mediated cytotoxicity |
| negative regulation of T cell mediated immunity |
| lymph vessel development |
| negative regulation of cell killing |
| regulation of synaptic vesicle recycling |
| inositol phosphate-mediated signaling |
| T cell homeostasis |
| positive regulation of insulin secretion involved in cellular response to glucose stimulus |
| regulation of T cell mediated cytotoxicity |
| axon extension |
| Wnt signaling pathway, calcium modulating pathway |
| T cell proliferation |
| negative regulation of lymphocyte mediated immunity |
| negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| calcium-ion regulated exocytosis |
| T-tubule |
| negative regulation of adaptive immune response |
| negative regulation of leukocyte mediated immunity |
| lymphocyte homeostasis |
| drug binding |
| regulation of insulin secretion involved in cellular response to glucose stimulus |
| neuron projection extension |
| protein serine/threonine phosphatase activity |
| leukocyte homeostasis |
| regulation of T cell mediated immunity |
| positive regulation of insulin secretion |
| regulation of leukocyte mediated cytotoxicity |
| lymphocyte proliferation |
| mononuclear cell proliferation |
| developmental cell growth |
| cell growth |
| positive regulation of peptide hormone secretion |
| leukocyte proliferation |
| regulation of cell killing |
| regulation of synaptic vesicle cycle |
| developmental growth involved in morphogenesis |
| memory |
| negative regulation of immune effector process |
| positive regulation of hormone secretion |
| Z disc |
| non-canonical Wnt signaling pathway |
| T cell differentiation |
| regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains |
| learning |
| calcium-mediated signaling |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| protein dimerization activity |
| regulation of adaptive immune response |
| Fc-epsilon receptor signaling pathway |
| regulation of insulin secretion |
| regulation of synaptic plasticity |
| locomotory behavior |
| homeostasis of number of cells |
| calmodulin binding |
| regulation of leukocyte mediated immunity |
| regulation of endocytosis |
| regulation of peptide hormone secretion |
| protein dephosphorylation |
| T cell activation |
| lymphocyte differentiation |
| Fc receptor signaling pathway |
| learning or memory |
| regulation of hormone secretion |
| positive regulation of protein secretion |
| positive regulation of peptide secretion |
| cognition |
| dephosphorylation |
| leukocyte differentiation |
| second-messenger-mediated signaling |
| glutamatergic synapse |
| enzyme binding |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| axonogenesis |
| lymphocyte activation |
| developmental growth |
| growth |
| cellular response to drug |
| positive regulation of secretion by cell |
| axon development |
| positive regulation of protein transport |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| cell morphogenesis involved in neuron differentiation |
| positive regulation of secretion |
| negative regulation of immune system process |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| regulation of peptide secretion |
| vasculature development |
| cell part morphogenesis |
| cardiovascular system development |
| heart development |
| regulation of hormone levels |
| regulation of vesicle-mediated transport |
| cell population proliferation |
| cell morphogenesis involved in differentiation |
| hemopoiesis |
| behavior |
| immune response-regulating signaling pathway |
| hematopoietic or lymphoid organ development |
| immune system development |
| neuron projection development |
| regulated exocytosis |
| regulation of protein transport |
| calcium ion binding |
| cell morphogenesis |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| exocytosis |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| regulation of cellular localization |
| leukocyte activation |
| protein phosphorylation |
| positive regulation of transport |
| secretion by cell |
| neuron differentiation |
| response to drug |
| regulation of protein localization |
| export from cell |
| cell activation |
| response to cytokine |
| cell-cell signaling |
| plasma membrane bounded cell projection organization |
| secretion |
| regulation of immune response |
| cell projection organization |
| positive regulation of transcription by RNA polymerase II |
| phosphorylation |
| locomotion |
| nervous system process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| negative regulation of response to stimulus |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| cell development |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of RNA metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of transport |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| vesicle-mediated transport |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mdivi-1 15μM R05 exp217 | 2.48 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18600
- Expression level (log2 read counts): 5.81
Expression Distribution
PPP3CB Expression in NALM6 Cells: 5.81
