PRG3
Gene Information
- Official Symbol: PRG3
- Official Name: proteoglycan 3, pro eosinophil major basic protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 10394
- UniProt: Q9Y2Y8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. {ECO:0000269|PubMed:10318872}.
Pfam Domains GO Terms
Pfam Domains
| Lectin C |
GO Terms
| histamine biosynthetic process |
| basophil activation |
| histamine metabolic process |
| positive regulation of interleukin-8 biosynthetic process |
| imidazole-containing compound metabolic process |
| superoxide anion generation |
| extracellular matrix structural constituent conferring compression resistance |
| regulation of interleukin-8 biosynthetic process |
| leukotriene biosynthetic process |
| cellular biogenic amine biosynthetic process |
| amine biosynthetic process |
| leukotriene metabolic process |
| superoxide metabolic process |
| neurotransmitter biosynthetic process |
| icosanoid biosynthetic process |
| positive regulation of interleukin-8 production |
| tertiary granule lumen |
| cellular biogenic amine metabolic process |
| cellular amine metabolic process |
| specific granule lumen |
| amine metabolic process |
| positive regulation of cytokine biosynthetic process |
| regulation of interleukin-8 production |
| neurotransmitter metabolic process |
| fatty acid derivative biosynthetic process |
| regulation of cytokine biosynthetic process |
| icosanoid metabolic process |
| reactive oxygen species metabolic process |
| negative regulation of translation |
| negative regulation of cellular amide metabolic process |
| fatty acid derivative metabolic process |
| carbohydrate binding |
| ammonium ion metabolic process |
| carboxylic acid biosynthetic process |
| organic acid biosynthetic process |
| regulation of neurotransmitter levels |
| regulation of translation |
| collagen-containing extracellular matrix |
| regulation of cellular amide metabolic process |
| positive regulation of cytokine production |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| neutrophil activation |
| granulocyte activation |
| leukocyte degranulation |
| myeloid leukocyte mediated immunity |
| myeloid cell activation involved in immune response |
| posttranscriptional regulation of gene expression |
| myeloid leukocyte activation |
| small molecule biosynthetic process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cytokine production |
| regulated exocytosis |
| leukocyte mediated immunity |
| exocytosis |
| carboxylic acid metabolic process |
| leukocyte activation |
| oxoacid metabolic process |
| secretion by cell |
| organic acid metabolic process |
| negative regulation of cellular protein metabolic process |
| export from cell |
| cell activation |
| immune effector process |
| negative regulation of protein metabolic process |
| secretion |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| organic cyclic compound biosynthetic process |
| negative regulation of cellular macromolecule biosynthetic process |
| organonitrogen compound biosynthetic process |
| negative regulation of macromolecule biosynthetic process |
| negative regulation of cellular biosynthetic process |
| negative regulation of biosynthetic process |
| cellular nitrogen compound biosynthetic process |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| immune response |
| positive regulation of macromolecule biosynthetic process |
| extracellular region |
| vesicle-mediated transport |
| positive regulation of cellular biosynthetic process |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Dimethyl-Sulfoxide 1pc R03 exp120 | 1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 16124
- Expression level (log2 read counts): -6.6
Expression Distribution
PRG3 Expression in NALM6 Cells: -6.6
