PRKACB
Gene Information
- Official Symbol: PRKACB
- Official Name: protein kinase cAMP-activated catalytic subunit beta
- Aliases and Previous Symbols: N/A
- Entrez ID: 5567
- UniProt: P22694
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase Tyr |
| Pkinase |
GO Terms
| response to clozapine |
| response to antipsychotic drug |
| negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning |
| cAMP-dependent protein kinase activity |
| cAMP-dependent protein kinase complex |
| protein kinase A signaling |
| high-density lipoprotein particle assembly |
| negative regulation of meiotic cell cycle |
| activation of protein kinase A activity |
| protein kinase A regulatory subunit binding |
| negative regulation of embryonic development |
| plasma lipoprotein particle assembly |
| cellular response to glucagon stimulus |
| protein-lipid complex assembly |
| negative regulation of smoothened signaling pathway |
| renal water homeostasis |
| ciliary base |
| response to glucagon |
| plasma lipoprotein particle organization |
| protein-lipid complex subunit organization |
| regulation of meiotic cell cycle |
| negative regulation of reproductive process |
| intercellular bridge |
| regulation of protein processing |
| multicellular organismal water homeostasis |
| regulation of protein maturation |
| regulation of plasma lipoprotein particle levels |
| water homeostasis |
| regulation of smoothened signaling pathway |
| neural tube closure |
| tube closure |
| primary neural tube formation |
| neural tube formation |
| renal system process |
| stimulatory C-type lectin receptor signaling pathway |
| innate immune response activating cell surface receptor signaling pathway |
| embryonic epithelial tube formation |
| regulation of embryonic development |
| epithelial tube formation |
| morphogenesis of embryonic epithelium |
| tube formation |
| neural tube development |
| regulation of reproductive process |
| peptidyl-serine phosphorylation |
| peptidyl-serine modification |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| magnesium ion binding |
| innate immune response-activating signal transduction |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| activation of innate immune response |
| cellular response to peptide hormone stimulus |
| ubiquitin protein ligase binding |
| blood coagulation |
| coagulation |
| hemostasis |
| response to xenobiotic stimulus |
| epithelial tube morphogenesis |
| negative regulation of nervous system development |
| multicellular organismal homeostasis |
| cellular response to peptide |
| activation of protein kinase activity |
| positive regulation of innate immune response |
| positive regulation of response to biotic stimulus |
| extracellular structure organization |
| response to peptide hormone |
| morphogenesis of an epithelium |
| immune response-activating cell surface receptor signaling pathway |
| regulation of innate immune response |
| response to peptide |
| positive regulation of defense response |
| wound healing |
| immune response-regulating cell surface receptor signaling pathway |
| centrosome |
| regulation of body fluid levels |
| positive regulation of multi-organism process |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| immune response-activating signal transduction |
| tissue morphogenesis |
| embryonic morphogenesis |
| response to wounding |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| positive regulation of response to external stimulus |
| cellular response to hormone stimulus |
| activation of immune response |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| perinuclear region of cytoplasm |
| regulation of proteolysis |
| regulation of defense response |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| tube development |
| positive regulation of immune response |
| regulation of kinase activity |
| peptidyl-amino acid modification |
| anatomical structure formation involved in morphogenesis |
| response to hormone |
| response to organic cyclic compound |
| regulation of nervous system development |
| negative regulation of developmental process |
| protein phosphorylation |
| embryo development |
| regulation of transferase activity |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| response to drug |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| response to nitrogen compound |
| regulation of response to external stimulus |
| chemical homeostasis |
| epithelium development |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of immune response |
| positive regulation of immune system process |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| phosphorylation |
| G protein-coupled receptor signaling pathway |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| ATP binding |
| response to oxygen-containing compound |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| negative regulation of response to stimulus |
| homeostatic process |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| MS023 7μM R03 exp135 | 1.75 |
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 18514
- Expression level (log2 read counts): 2.86
Expression Distribution
PRKACB Expression in NALM6 Cells: 2.86
