Entrez Summary: This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is expressed in the brain and pancreas and is resistant to common trypsin inhibitors. It is active on peptide linkages involving the carboxyl group of lysine or arginine. This gene is localized to the locus of T cell receptor beta variable orphans on chromosome 9. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2010].
UniProt Summary: N/A
Pfam DomainsGO Terms
Pfam Domains
Trypsin
GO Terms
cobalamin metabolic process
zymogen activation
tertiary granule lumen
tetrapyrrole metabolic process
endothelial cell migration
epithelial cell migration
epithelium migration
water-soluble vitamin metabolic process
tissue migration
antimicrobial humoral response
digestion
vitamin metabolic process
protein processing
serine-type endopeptidase activity
ameboidal-type cell migration
protein maturation
humoral immune response
cofactor metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
drug metabolic process
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
calcium ion binding
leukocyte mediated immunity
exocytosis
leukocyte activation
cell migration
secretion by cell
export from cell
cell activation
localization of cell
cell motility
immune effector process
secretion
proteolysis
response to other organism
response to external biotic stimulus
locomotion
response to biotic stimulus
movement of cell or subcellular component
extracellular space
small molecule metabolic process
immune response
extracellular region
vesicle-mediated transport
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)