PTK7

Gene Information

Official Symbol: PTK7
Official Name: protein tyrosine kinase 7 (inactive)
Aliases and Previous Symbols: N/A
Entrez ID: 5754
UniProt: Q13308
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: N/A

Pfam Domains GO Terms

Pfam Domains

I-set

Pkinase

Pkinase Tyr

GO Terms

coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway

lung-associated mesenchyme development

planar cell polarity pathway involved in neural tube closure

convergent extension

regulation of establishment of planar polarity involved in neural tube closure

establishment of epithelial cell apical/basal polarity

regulation of epithelial tube formation

polarized epithelial cell differentiation

establishment of apical/basal cell polarity

establishment of monopolar cell polarity

establishment or maintenance of monopolar cell polarity

establishment of planar polarity

establishment of tissue polarity

cochlea morphogenesis

axis elongation

establishment of epithelial cell polarity

morphogenesis of a polarized epithelium

coronary vasculature development

establishment or maintenance of epithelial cell apical/basal polarity

establishment or maintenance of apical/basal cell polarity

establishment or maintenance of bipolar cell polarity

cochlea development

actin cytoskeleton reorganization

cellular response to retinoic acid

ventricular septum development

neural tube closure

tube closure

Wnt signaling pathway, planar cell polarity pathway

inner ear morphogenesis

primary neural tube formation

neural tube formation

response to retinoic acid

cardiac septum development

regulation of establishment of planar polarity

developmental growth involved in morphogenesis

ear morphogenesis

establishment of cell polarity

embryonic epithelial tube formation

cardiac ventricle development

regulation of embryonic development

epithelial tube formation

non-canonical Wnt signaling pathway

positive regulation of canonical Wnt signaling pathway

morphogenesis of embryonic epithelium

tube formation

neural tube development

lung development

cardiac chamber development

cell-cell junction

respiratory tube development

positive regulation of Wnt signaling pathway

regulation of morphogenesis of an epithelium

inner ear development

respiratory system development

establishment or maintenance of cell polarity

cellular response to acid chemical

ear development

mesenchyme development

protein kinase activity

sensory organ morphogenesis

regulation of animal organ morphogenesis

positive regulation of neuron projection development

regulation of canonical Wnt signaling pathway

embryonic organ morphogenesis

epithelial tube morphogenesis

response to acid chemical

Wnt signaling pathway

cell-cell signaling by wnt

regulation of Wnt signaling pathway

positive regulation of neuron differentiation

positive regulation of cell projection organization

developmental growth

growth

focal adhesion

cell surface receptor signaling pathway involved in cell-cell signaling

morphogenesis of an epithelium

embryonic organ development

positive regulation of neurogenesis

wound healing

blood vessel development

actin cytoskeleton organization

regulation of neuron projection development

vasculature development

cardiovascular system development

cellular response to lipid

heart development

positive regulation of nervous system development

positive regulation of cell development

sensory organ development

tissue morphogenesis

embryonic morphogenesis

actin filament-based process

response to wounding

chordate embryonic development

embryo development ending in birth or egg hatching

tube morphogenesis

regulation of neuron differentiation

epithelial cell differentiation

regulation of plasma membrane bounded cell projection organization

regulation of cell projection organization

regulation of neurogenesis

tube development

response to lipid

circulatory system development

anatomical structure formation involved in morphogenesis

regulation of nervous system development

cell adhesion

regulation of cell development

biological adhesion

animal organ morphogenesis

cell migration

positive regulation of cell differentiation

protein phosphorylation

embryo development

cellular response to oxygen-containing compound

regulation of anatomical structure morphogenesis

localization of cell

cell motility

cytoskeleton organization

epithelium development

cell-cell signaling

positive regulation of cellular component organization

phosphorylation

locomotion

positive regulation of developmental process

integral component of plasma membrane

ATP binding

generation of neurons

movement of cell or subcellular component

response to oxygen-containing compound

neurogenesis

positive regulation of signal transduction

positive regulation of multicellular organismal process

tissue development

regulation of cell differentiation

positive regulation of cell communication

positive regulation of signaling

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Compound Hit

No hits were found.

Most Correlated Genes in Chemogenomics

No correlation found to any other genes in chemogenomics.

Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 12418
Expression level (log2 read counts): 6.86

Expression Distribution