PTN
Gene Information
- Official Symbol: PTN
- Official Name: pleiotrophin
- Aliases and Previous Symbols: N/A
- Entrez ID: 5764
- UniProt: P21246
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777). {ECO:0000269|PubMed:11278720, ECO:0000269|PubMed:16814777, ECO:0000269|PubMed:1768439, ECO:0000269|PubMed:26896299}.
Pfam Domains GO Terms
Pfam Domains
| PTN MK N |
| PTN MK C |
GO Terms
| rod bipolar cell differentiation |
| response to kainic acid |
| response to ciliary neurotrophic factor |
| dendrite regeneration |
| negative regulation of neuromuscular junction development |
| positive regulation of skeletal muscle acetylcholine-gated channel clustering |
| retinal rod cell differentiation |
| chondroitin sulfate proteoglycan binding |
| heparan sulfate binding |
| positive regulation of postsynaptic membrane organization |
| ossification involved in bone remodeling |
| retinal bipolar neuron differentiation |
| leukocyte chemotaxis involved in inflammatory response |
| regulation of skeletal muscle acetylcholine-gated channel clustering |
| positive regulation of neuromuscular junction development |
| transmembrane receptor protein tyrosine phosphatase signaling pathway |
| positive regulation of receptor clustering |
| dendrite arborization |
| vascular endothelial growth factor binding |
| syndecan binding |
| negative regulation of neuroblast proliferation |
| positive regulation of hepatocyte proliferation |
| negative regulation of mesenchymal cell proliferation |
| positive regulation of axon regeneration |
| positive regulation of neuron projection regeneration |
| chondroitin sulfate binding |
| regulation of neuromuscular junction development |
| neuron projection arborization |
| negative regulation of long-term synaptic potentiation |
| regulation of receptor clustering |
| thalamus development |
| negative regulation of stem cell proliferation |
| negative regulation of membrane potential |
| leukocyte migration involved in inflammatory response |
| regulation of hepatocyte proliferation |
| negative regulation of glial cell proliferation |
| regulation of postsynaptic membrane organization |
| cellular response to vitamin D |
| estrous cycle |
| camera-type eye photoreceptor cell differentiation |
| cellular response to platelet-derived growth factor stimulus |
| response to platelet-derived growth factor |
| positive regulation of stem cell differentiation |
| positive regulation of oligodendrocyte differentiation |
| negative regulation of neural precursor cell proliferation |
| cellular response to vitamin |
| negative regulation of synapse organization |
| decidualization |
| regulation of axon regeneration |
| response to auditory stimulus |
| regulation of stem cell population maintenance |
| neuron projection regeneration |
| regulation of neuron projection regeneration |
| regulation of glial cell proliferation |
| response to vitamin D |
| regulation of neuroblast proliferation |
| regulation of mesenchymal cell proliferation |
| protein phosphatase inhibitor activity |
| maternal placenta development |
| positive regulation of bone mineralization |
| regulation of oligodendrocyte differentiation |
| negative regulation of gliogenesis |
| positive regulation of glial cell differentiation |
| regulation of myelination |
| regulation of long-term synaptic potentiation |
| response to progesterone |
| eye photoreceptor cell differentiation |
| bone remodeling |
| receptor clustering |
| positive regulation of biomineral tissue development |
| long-term synaptic potentiation |
| positive regulation of biomineralization |
| bone mineralization |
| retina morphogenesis in camera-type eye |
| response to nerve growth factor |
| neural retina development |
| photoreceptor cell differentiation |
| dendrite morphogenesis |
| negative regulation of phosphoprotein phosphatase activity |
| tissue regeneration |
| positive regulation of response to wounding |
| maternal process involved in female pregnancy |
| regulation of stem cell proliferation |
| response to activity |
| negative regulation of protein dephosphorylation |
| ovulation cycle |
| cellular response to nutrient |
| regulation of glial cell differentiation |
| positive regulation of gliogenesis |
| positive regulation of dendrite development |
| regulation of bone mineralization |
| diencephalon development |
| neuromuscular junction |
| oogenesis |
| positive regulation of animal organ morphogenesis |
| endothelial cell differentiation |
| postsynapse |
| cellular response to UV |
| positive regulation of ossification |
| localization within membrane |
| response to vitamin |
| positive regulation of cell division |
| regulation of neural precursor cell proliferation |
| positive regulation of leukocyte chemotaxis |
| basement membrane |
| regulation of biomineral tissue development |
| biomineral tissue development |
| regulation of biomineralization |
| biomineralization |
| integrin-mediated signaling pathway |
| presynapse |
| endothelium development |
| regulation of postsynapse organization |
| tissue remodeling |
| cerebellum development |
| dendrite development |
| negative regulation of angiogenesis |
| negative regulation of phosphatase activity |
| negative regulation of blood vessel morphogenesis |
| spinal cord development |
| negative regulation of dephosphorylation |
| metencephalon development |
| camera-type eye morphogenesis |
| regulation of leukocyte chemotaxis |
| cellular response to light stimulus |
| response to amino acid |
| negative regulation of vasculature development |
| regulation of gliogenesis |
| regulation of stem cell differentiation |
| regulation of phosphoprotein phosphatase activity |
| memory |
| positive regulation of cell-substrate adhesion |
| positive regulation of protein localization to membrane |
| negative regulation of epithelial cell proliferation |
| liver development |
| hepaticobiliary system development |
| positive regulation of leukocyte migration |
| female gamete generation |
| integrin binding |
| positive regulation of chemotaxis |
| response to estradiol |
| retina development in camera-type eye |
| regulation of protein dephosphorylation |
| response to UV |
| leukocyte chemotaxis |
| learning |
| eye morphogenesis |
| regulation of dendrite development |
| positive regulation of synaptic transmission |
| hindbrain development |
| placenta development |
| regulation of cell shape |
| regeneration |
| regulation of endothelial cell migration |
| growth factor activity |
| regulation of response to wounding |
| regulation of cell division |
| lung development |
| heparin binding |
| respiratory tube development |
| cellular response to radiation |
| regulation of phosphatase activity |
| female pregnancy |
| cellular response to hypoxia |
| positive regulation of epithelial cell proliferation |
| regulation of synaptic plasticity |
| regulation of protein localization to membrane |
| regulation of ossification |
| response to ketone |
| regulation of leukocyte migration |
| respiratory system development |
| cellular response to decreased oxygen levels |
| cell chemotaxis |
| regulation of dephosphorylation |
| multi-multicellular organism process |
| regulation of cell-substrate adhesion |
| response to mechanical stimulus |
| regulation of chemotaxis |
| response to nutrient |
| cellular response to oxygen levels |
| regulation of synapse organization |
| regulation of epithelial cell migration |
| regulation of synapse structure or activity |
| cellular response to nutrient levels |
| germ cell development |
| sensory organ morphogenesis |
| regulation of animal organ morphogenesis |
| negative regulation of cell migration |
| learning or memory |
| ossification |
| cellular response to extracellular stimulus |
| negative regulation of cell motility |
| rhythmic process |
| positive regulation of neuron projection development |
| regulation of angiogenesis |
| negative regulation of neurogenesis |
| cognition |
| response to light stimulus |
| negative regulation of cellular component movement |
| negative regulation of nervous system development |
| camera-type eye development |
| cellular response to environmental stimulus |
| cellular response to abiotic stimulus |
| regulation of vasculature development |
| negative regulation of locomotion |
| positive regulation of cellular protein localization |
| response to steroid hormone |
| regulation of epithelial cell proliferation |
| negative regulation of cell development |
| cellular response to external stimulus |
| response to hypoxia |
| response to acid chemical |
| cellular process involved in reproduction in multicellular organism |
| response to decreased oxygen levels |
| eye development |
| visual system development |
| sensory system development |
| positive regulation of neuron differentiation |
| leukocyte migration |
| response to oxygen levels |
| positive regulation of cell projection organization |
| forebrain development |
| developmental growth |
| growth |
| positive regulation of cell adhesion |
| gland development |
| reproductive structure development |
| reproductive system development |
| regulation of membrane potential |
| cell morphogenesis involved in neuron differentiation |
| response to radiation |
| modulation of chemical synaptic transmission |
| regulation of trans-synaptic signaling |
| regulation of hemopoiesis |
| negative regulation of hydrolase activity |
| protein kinase binding |
| positive regulation of neurogenesis |
| wound healing |
| neuron projection morphogenesis |
| protein localization to membrane |
| plasma membrane bounded cell projection morphogenesis |
| regulation of cell morphogenesis |
| cell projection morphogenesis |
| regulation of neuron projection development |
| inflammatory response |
| response to nutrient levels |
| positive regulation of cell migration |
| cellular response to growth factor stimulus |
| cell part morphogenesis |
| cellular response to lipid |
| positive regulation of cell motility |
| heart development |
| response to growth factor |
| response to extracellular stimulus |
| positive regulation of nervous system development |
| positive regulation of cellular component movement |
| regulation of cellular protein localization |
| positive regulation of cell development |
| cellular response to organic cyclic compound |
| sensory organ development |
| chemotaxis |
| taxis |
| positive regulation of locomotion |
| cell morphogenesis involved in differentiation |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| response to wounding |
| behavior |
| negative regulation of protein modification process |
| protein-containing complex |
| positive regulation of response to external stimulus |
| cell surface |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| regulation of neuron differentiation |
| neuron projection development |
| developmental process involved in reproduction |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| regulation of cell adhesion |
| gamete generation |
| regulation of plasma membrane bounded cell projection organization |
| positive regulation of cell death |
| perinuclear region of cytoplasm |
| negative regulation of cellular component organization |
| regulation of cell projection organization |
| negative regulation of cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of cellular response to stress |
| brain development |
| head development |
| negative regulation of catalytic activity |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| multicellular organismal reproductive process |
| sexual reproduction |
| multicellular organism reproduction |
| tube development |
| regulation of cell migration |
| response to lipid |
| circulatory system development |
| response to hormone |
| regulation of cell motility |
| regulation of cellular localization |
| positive regulation of cell population proliferation |
| response to organic cyclic compound |
| regulation of nervous system development |
| regulation of cell development |
| negative regulation of developmental process |
| animal organ morphogenesis |
| cell migration |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| multi-organism reproductive process |
| response to organonitrogen compound |
| endoplasmic reticulum |
| neuron differentiation |
| response to drug |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| epithelium development |
| plasma membrane bounded cell projection organization |
| negative regulation of molecular function |
| positive regulation of immune system process |
| response to abiotic stimulus |
| cell projection organization |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| regulation of hydrolase activity |
| locomotion |
| defense response |
| positive regulation of developmental process |
| nervous system process |
| reproductive process |
| reproduction |
| response to endogenous stimulus |
| regulation of response to stress |
| generation of neurons |
| regulation of apoptotic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| cellular protein localization |
| cellular macromolecule localization |
| extracellular space |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| regulation of immune system process |
| regulation of cell death |
| cellular response to stress |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of protein modification process |
| extracellular region |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 13559
- Expression level (log2 read counts): -4.6
Expression Distribution
PTN Expression in NALM6 Cells: -4.6
