UniProt Summary: Tyrosine-protein phosphatase targeted to sites of actin polymerization in response of varied extracellular stimuli. Has tyrosine phosphatase activity towards various tyrosyl phosphorylated substrates.
Pfam DomainsGO Terms
Pfam Domains
Y phosphatase
GO Terms
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
microtubule organizing center
protein dephosphorylation
dephosphorylation
microtubule
cellular response to cytokine stimulus
response to cytokine
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739