PTPN22
Gene Information
- Official Symbol: PTPN22
- Official Name: protein tyrosine phosphatase non-receptor type 22
- Aliases and Previous Symbols: N/A
- Entrez ID: 26191
- UniProt: Q9Y2R2
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Y phosphatase |
GO Terms
| phosphoanandamide dephosphorylation |
| negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| negative regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| positive regulation of protein K63-linked ubiquitination |
| negative regulation of p38MAPK cascade |
| regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| positive regulation of toll-like receptor 3 signaling pathway |
| negative regulation of interleukin-8 secretion |
| positive regulation of interferon-gamma secretion |
| positive regulation of toll-like receptor 4 signaling pathway |
| cellular response to muramyl dipeptide |
| regulation of natural killer cell proliferation |
| regulation of nucleotide-binding oligomerization domain containing signaling pathway |
| regulation of toll-like receptor 3 signaling pathway |
| regulation of protein K63-linked ubiquitination |
| negative regulation of interleukin-6 secretion |
| regulation of interferon-gamma secretion |
| positive regulation of protein polyubiquitination |
| negative regulation of JUN kinase activity |
| negative regulation of interleukin-8 production |
| negative regulation of T cell receptor signaling pathway |
| response to muramyl dipeptide |
| regulation of toll-like receptor 4 signaling pathway |
| regulation of protein polyubiquitination |
| positive regulation of toll-like receptor signaling pathway |
| regulation of interleukin-8 secretion |
| regulation of B cell receptor signaling pathway |
| negative regulation of antigen receptor-mediated signaling pathway |
| regulation of natural killer cell activation |
| lipopolysaccharide-mediated signaling pathway |
| negative regulation of JNK cascade |
| regulation of T cell receptor signaling pathway |
| regulation of p38MAPK cascade |
| negative regulation of interleukin-6 production |
| negative regulation of stress-activated MAPK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| phosphatase activity |
| cytoplasmic side of plasma membrane |
| negative regulation of tumor necrosis factor production |
| negative regulation of tumor necrosis factor superfamily cytokine production |
| regulation of antigen receptor-mediated signaling pathway |
| positive regulation of interferon-gamma production |
| regulation of toll-like receptor signaling pathway |
| negative regulation of cytokine secretion |
| regulation of interleukin-8 production |
| negative regulation of MAP kinase activity |
| positive regulation of type I interferon production |
| negative regulation of autophagy |
| regulation of JUN kinase activity |
| kinase binding |
| regulation of interferon-gamma production |
| protein tyrosine phosphatase activity |
| peptidyl-tyrosine dephosphorylation |
| regulation of NIK/NF-kappaB signaling |
| negative regulation of T cell activation |
| positive regulation of protein ubiquitination |
| negative regulation of leukocyte cell-cell adhesion |
| regulation of type I interferon production |
| SH3 domain binding |
| negative regulation of protein secretion |
| negative regulation of protein serine/threonine kinase activity |
| positive regulation of protein modification by small protein conjugation or removal |
| T cell differentiation |
| negative regulation of peptide secretion |
| positive regulation of cytokine secretion |
| regulation of interleukin-6 production |
| negative regulation of lymphocyte activation |
| regulation of tumor necrosis factor production |
| regulation of tumor necrosis factor superfamily cytokine production |
| negative regulation of MAPK cascade |
| negative regulation of cell-cell adhesion |
| negative regulation of leukocyte activation |
| T cell receptor signaling pathway |
| negative regulation of protein transport |
| cellular response to lipopolysaccharide |
| regulation of JNK cascade |
| negative regulation of establishment of protein localization |
| cellular response to molecule of bacterial origin |
| negative regulation of cell activation |
| regulation of protein ubiquitination |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| positive regulation of ERK1 and ERK2 cascade |
| protein dephosphorylation |
| cellular response to biotic stimulus |
| regulation of leukocyte proliferation |
| negative regulation of protein kinase activity |
| regulation of protein modification by small protein conjugation or removal |
| negative regulation of secretion |
| regulation of stress-activated MAPK cascade |
| T cell activation |
| regulation of stress-activated protein kinase signaling cascade |
| lymphocyte differentiation |
| negative regulation of kinase activity |
| negative regulation of cellular catabolic process |
| autophagy |
| process utilizing autophagic mechanism |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| negative regulation of cytokine production |
| negative regulation of transferase activity |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| ubiquitin protein ligase binding |
| antigen receptor-mediated signaling pathway |
| regulation of leukocyte cell-cell adhesion |
| dephosphorylation |
| negative regulation of catabolic process |
| response to lipopolysaccharide |
| regulation of T cell activation |
| response to molecule of bacterial origin |
| cellular response to peptide |
| leukocyte differentiation |
| regulation of autophagy |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| positive regulation of response to biotic stimulus |
| lymphocyte activation |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| cellular response to drug |
| negative regulation of protein phosphorylation |
| positive regulation of protein transport |
| positive regulation of secretion |
| negative regulation of immune system process |
| negative regulation of phosphorylation |
| immune response-activating cell surface receptor signaling pathway |
| positive regulation of cytokine production |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| response to peptide |
| positive regulation of defense response |
| immune response-regulating cell surface receptor signaling pathway |
| negative regulation of transport |
| regulation of peptide secretion |
| negative regulation of intracellular signal transduction |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| cellular response to lipid |
| regulation of response to biotic stimulus |
| positive regulation of MAPK cascade |
| hemopoiesis |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| immune response-activating signal transduction |
| negative regulation of protein modification process |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| hematopoietic or lymphoid organ development |
| activation of immune response |
| regulation of cell activation |
| immune system development |
| cellular response to nitrogen compound |
| regulation of cell adhesion |
| response to bacterium |
| regulation of cytokine production |
| perinuclear region of cytoplasm |
| regulation of protein transport |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| regulation of multi-organism process |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cellular catabolic process |
| response to lipid |
| positive regulation of immune response |
| regulation of kinase activity |
| leukocyte activation |
| regulation of transferase activity |
| positive regulation of transport |
| regulation of catabolic process |
| response to organonitrogen compound |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| negative regulation of molecular function |
| positive regulation of immune system process |
| regulation of immune response |
| negative regulation of multicellular organismal process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| regulation of response to stress |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| regulation of immune system process |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| regulation of transport |
| positive regulation of gene expression |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| A-366 10μM R03 exp115 | 1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15952
- Expression level (log2 read counts): 2.77
Expression Distribution
PTPN22 Expression in NALM6 Cells: 2.77
