PYDC1
Gene Information
- Official Symbol: PYDC1
- Official Name: pyrin domain containing 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 260434
- UniProt: Q8WXC3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. Suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS. {ECO:0000269|PubMed:12656673, ECO:0000269|PubMed:24871464}.
Pfam Domains GO Terms
Pfam Domains
| PAAD DAPIN |
GO Terms
| negative regulation of NLRP3 inflammasome complex assembly |
| IkappaB kinase complex |
| regulation of NLRP3 inflammasome complex assembly |
| negative regulation of interleukin-1 beta secretion |
| negative regulation of interleukin-1 secretion |
| negative regulation of tumor necrosis factor-mediated signaling pathway |
| negative regulation of interleukin-1 beta production |
| positive regulation of interleukin-1 beta secretion |
| negative regulation of interleukin-1 production |
| positive regulation of interleukin-1 secretion |
| regulation of interleukin-1 beta secretion |
| positive regulation of interleukin-1 beta production |
| regulation of interleukin-1 secretion |
| positive regulation of interleukin-1 production |
| regulation of tumor necrosis factor-mediated signaling pathway |
| negative regulation of cytokine-mediated signaling pathway |
| negative regulation of response to cytokine stimulus |
| negative regulation of cytokine secretion |
| regulation of interleukin-1 beta production |
| negative regulation of NF-kappaB transcription factor activity |
| cysteine-type endopeptidase activity |
| regulation of interleukin-1 production |
| tumor necrosis factor-mediated signaling pathway |
| negative regulation of protein complex assembly |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| positive regulation of cytokine secretion |
| negative regulation of DNA-binding transcription factor activity |
| regulation of cytokine-mediated signaling pathway |
| regulation of response to cytokine stimulus |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| negative regulation of protein kinase activity |
| negative regulation of secretion |
| cellular response to tumor necrosis factor |
| negative regulation of kinase activity |
| response to tumor necrosis factor |
| positive regulation of protein secretion |
| negative regulation of cytokine production |
| negative regulation of transferase activity |
| positive regulation of peptide secretion |
| positive regulation of secretion by cell |
| negative regulation of protein phosphorylation |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| negative regulation of phosphorylation |
| positive regulation of cytokine production |
| regulation of protein complex assembly |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| negative regulation of transport |
| regulation of peptide secretion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| negative regulation of protein modification process |
| cytokine-mediated signaling pathway |
| regulation of cytokine production |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| innate immune response |
| negative regulation of catalytic activity |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of kinase activity |
| defense response to other organism |
| regulation of cellular component biogenesis |
| regulation of transferase activity |
| positive regulation of transport |
| cellular response to cytokine stimulus |
| regulation of protein localization |
| negative regulation of cellular protein metabolic process |
| response to cytokine |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| negative regulation of multicellular organismal process |
| negative regulation of signal transduction |
| proteolysis |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| defense response |
| negative regulation of cell communication |
| negative regulation of signaling |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| negative regulation of response to stimulus |
| positive regulation of multicellular organismal process |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of protein modification process |
| regulation of transport |
| immune response |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11983
- Expression level (log2 read counts): -4.6
Expression Distribution
PYDC1 Expression in NALM6 Cells: -4.6
