QPCT
Gene Information
- Official Symbol: QPCT
- Official Name: glutaminyl-peptide cyclotransferase
- Aliases and Previous Symbols: N/A
- Entrez ID: 25797
- UniProt: Q16769
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. {ECO:0000269|PubMed:15063747, ECO:0000269|PubMed:18486145, ECO:0000269|PubMed:21288892}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15189
- Expression level (log2 read counts): -5.6
QPCT Expression in NALM6 Cells: -5.6
