RAB11FIP4
Gene Information
- Official Symbol: RAB11FIP4
- Official Name: RAB11 family interacting protein 4
- Aliases and Previous Symbols: N/A
- Entrez ID: 84440
- UniProt: Q86YS3
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016].
- UniProt Summary: Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. {ECO:0000269|PubMed:12470645}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 9987
- Expression level (log2 read counts): 2.92
RAB11FIP4 Expression in NALM6 Cells: 2.92
