RASGRF2
Gene Information
- Official Symbol: RASGRF2
- Official Name: Ras protein specific guanine nucleotide releasing factor 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 5924
- UniProt: O14827
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways. [provided by RefSeq, Oct 2011].
- UniProt Summary: Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12976
- Expression level (log2 read counts): 1.52
RASGRF2 Expression in NALM6 Cells: 1.52
