RASGRP1
Gene Information
- Official Symbol: RASGRP1
- Official Name: RAS guanyl releasing protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 10125
- UniProt: O95267
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| RasGEF |
| C1 1 |
| RasGEF N |
GO Terms
| positive regulation of natural killer cell differentiation |
| positive regulation of interferon-gamma secretion |
| secretory granule localization |
| positive regulation of T cell differentiation in thymus |
| regulation of interferon-gamma secretion |
| diacylglycerol binding |
| positive regulation of granulocyte macrophage colony-stimulating factor production |
| regulation of natural killer cell differentiation |
| Ras guanyl-nucleotide exchange factor activity |
| regulation of granulocyte macrophage colony-stimulating factor production |
| mast cell degranulation |
| mast cell activation involved in immune response |
| mast cell mediated immunity |
| positive regulation of natural killer cell activation |
| mast cell granule |
| mast cell activation |
| inflammatory response to antigenic stimulus |
| regulation of T cell differentiation in thymus |
| phosphatidylcholine binding |
| positive regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell activation |
| positive regulation of natural killer cell mediated immunity |
| regulation of p38MAPK cascade |
| regulation of natural killer cell mediated cytotoxicity |
| vesicle transport along microtubule |
| lysosome localization |
| regulation of natural killer cell mediated immunity |
| regulation of phospholipase C activity |
| vesicle cytoskeletal trafficking |
| positive regulation of leukocyte mediated cytotoxicity |
| phosphatidylserine binding |
| positive regulation of interferon-gamma production |
| positive regulation of Ras protein signal transduction |
| positive regulation of cell killing |
| positive regulation of small GTPase mediated signal transduction |
| regulation of phospholipase activity |
| regulation of leukocyte mediated cytotoxicity |
| organelle transport along microtubule |
| positive regulation of T cell differentiation |
| positive regulation of tumor necrosis factor production |
| positive regulation of tumor necrosis factor superfamily cytokine production |
| positive regulation of lymphocyte differentiation |
| activation of GTPase activity |
| regulation of lipase activity |
| regulation of interferon-gamma production |
| regulation of cell killing |
| guanyl-nucleotide exchange factor activity |
| positive regulation of lymphocyte mediated immunity |
| regulation of phosphatidylinositol 3-kinase signaling |
| positive regulation of leukocyte mediated immunity |
| regulation of T cell differentiation |
| positive regulation of JNK cascade |
| positive regulation of cytokine secretion |
| positive regulation of leukocyte differentiation |
| regulation of tumor necrosis factor production |
| cytokine production |
| regulation of lymphocyte mediated immunity |
| regulation of tumor necrosis factor superfamily cytokine production |
| lipid binding |
| transport along microtubule |
| positive regulation of stress-activated MAPK cascade |
| positive regulation of stress-activated protein kinase signaling cascade |
| regulation of lymphocyte differentiation |
| establishment of vesicle localization |
| cytoskeleton-dependent intracellular transport |
| microtubule-based transport |
| vesicle localization |
| regulation of JNK cascade |
| positive regulation of hemopoiesis |
| positive regulation of T cell activation |
| regulation of cytokine secretion |
| regulation of leukocyte mediated immunity |
| positive regulation of ERK1 and ERK2 cascade |
| positive regulation of leukocyte cell-cell adhesion |
| positive regulation of immune effector process |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| regulation of Ras protein signal transduction |
| Ras protein signal transduction |
| positive regulation of cell-cell adhesion |
| positive regulation of MAP kinase activity |
| positive regulation of protein secretion |
| microtubule-based movement |
| regulation of leukocyte differentiation |
| positive regulation of peptide secretion |
| regulation of ERK1 and ERK2 cascade |
| regulation of leukocyte cell-cell adhesion |
| regulation of T cell activation |
| small GTPase mediated signal transduction |
| positive regulation of protein serine/threonine kinase activity |
| positive regulation of innate immune response |
| regulation of MAP kinase activity |
| regulation of small GTPase mediated signal transduction |
| positive regulation of lymphocyte activation |
| positive regulation of response to biotic stimulus |
| establishment of organelle localization |
| MAPK cascade |
| signal transduction by protein phosphorylation |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| positive regulation of leukocyte activation |
| positive regulation of cell adhesion |
| positive regulation of GTPase activity |
| positive regulation of cell activation |
| positive regulation of protein transport |
| positive regulation of secretion |
| positive regulation of cytokine production |
| regulation of hemopoiesis |
| regulation of innate immune response |
| positive regulation of establishment of protein localization |
| regulation of protein secretion |
| regulation of immune effector process |
| positive regulation of defense response |
| regulation of GTPase activity |
| regulation of peptide secretion |
| inflammatory response |
| positive regulation of multi-organism process |
| leukocyte degranulation |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| protein complex oligomerization |
| myeloid cell activation involved in immune response |
| regulation of response to biotic stimulus |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| organelle localization |
| myeloid leukocyte activation |
| regulation of leukocyte activation |
| positive regulation of response to external stimulus |
| Golgi membrane |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| regulation of cell activation |
| positive regulation of transferase activity |
| microtubule-based process |
| regulation of cell adhesion |
| regulation of cytokine production |
| regulated exocytosis |
| regulation of protein transport |
| calcium ion binding |
| regulation of cellular response to stress |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of MAPK cascade |
| regulation of defense response |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| exocytosis |
| regulation of protein kinase activity |
| regulation of secretion |
| zinc ion binding |
| positive regulation of immune response |
| regulation of kinase activity |
| protein homodimerization activity |
| leukocyte activation |
| endoplasmic reticulum membrane |
| positive regulation of cell differentiation |
| protein phosphorylation |
| regulation of transferase activity |
| Golgi apparatus |
| positive regulation of transport |
| secretion by cell |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| regulation of protein localization |
| export from cell |
| positive regulation of phosphorylation |
| cell activation |
| immune effector process |
| regulation of response to external stimulus |
| secretion |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| positive regulation of protein modification process |
| regulation of hydrolase activity |
| phosphorylation |
| defense response |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| intracellular transport |
| movement of cell or subcellular component |
| protein-containing complex assembly |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of immune system process |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
| immune response |
| vesicle-mediated transport |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Rapamycin 2μM R07 exp306 | -2.05 |
| LLY-283 2.6μM R06 exp290 | 2.16 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 1/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6231
- Expression level (log2 read counts): 0.69
Expression Distribution
RASGRP1 Expression in NALM6 Cells: 0.69
