UniProt Summary: Tissue-specific splicing factor with potential implication in the regulation of alternative splicing during neuron and germ cell differentiation. Antagonizes SRSF1-mediated BCL-X splicing. May affect the choice of alternative 5' splice sites by binding to specific sequences in exons and antagonizing the SR protein SRSF1. {ECO:0000269|PubMed:21984414}.
Pfam DomainsGO Terms
Pfam Domains
RRM 1
GO Terms
poly(U) RNA binding
single-stranded RNA binding
regulation of alternative mRNA splicing, via spliceosome
regulation of mRNA splicing, via spliceosome
regulation of RNA splicing
regulation of mRNA processing
cellular response to oxidative stress
regulation of mRNA metabolic process
response to oxidative stress
RNA splicing
nuclear speck
mRNA processing
mRNA metabolic process
RNA processing
protein homodimerization activity
RNA metabolic process
cellular response to stress
gene expression
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)