RGCC
Gene Information
- Official Symbol: RGCC
- Official Name: regulator of cell cycle
- Aliases and Previous Symbols: N/A
- Entrez ID: 28984
- UniProt: Q9H4X1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.
Pfam Domains GO Terms
Pfam Domains
No Pfam Domain information is available for this gene.
GO Terms
| negative regulation of exit from mitosis |
| negative regulation of fibroblast growth factor production |
| positive regulation of extracellular matrix constituent secretion |
| positive regulation of extracellular matrix assembly |
| fibroblast activation |
| regulation of extracellular matrix constituent secretion |
| negative regulation of cell-cell adhesion mediated by cadherin |
| regulation of fibroblast growth factor production |
| regulation of extracellular matrix assembly |
| mitotic cell cycle arrest |
| regulation of cell-cell adhesion mediated by cadherin |
| positive regulation of endothelial cell apoptotic process |
| regulation of exit from mitosis |
| positive regulation of extracellular matrix organization |
| R-SMAD binding |
| positive regulation of collagen biosynthetic process |
| positive regulation of collagen metabolic process |
| protein kinase activator activity |
| positive regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of blood vessel endothelial cell migration |
| positive regulation of epithelial cell apoptotic process |
| regulation of collagen biosynthetic process |
| positive regulation of cyclin-dependent protein kinase activity |
| positive regulation of G1/S transition of mitotic cell cycle |
| negative regulation of endothelial cell proliferation |
| regulation of extracellular matrix organization |
| negative regulation of mitotic nuclear division |
| regulation of collagen metabolic process |
| positive regulation of cell cycle G1/S phase transition |
| positive regulation of epithelial to mesenchymal transition |
| negative regulation of nuclear division |
| negative regulation of endothelial cell migration |
| regulation of endothelial cell apoptotic process |
| positive regulation of stress fiber assembly |
| positive regulation of mitotic nuclear division |
| DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| signal transduction involved in mitotic DNA integrity checkpoint |
| intracellular signal transduction involved in G1 DNA damage checkpoint |
| signal transduction involved in mitotic DNA damage checkpoint |
| signal transduction involved in mitotic G1 DNA damage checkpoint |
| signal transduction involved in mitotic cell cycle checkpoint |
| positive regulation of actin filament bundle assembly |
| mitotic G1/S transition checkpoint |
| mitotic G1 DNA damage checkpoint |
| G1 DNA damage checkpoint |
| positive regulation of nuclear division |
| negative regulation of epithelial cell migration |
| positive regulation of DNA biosynthetic process |
| negative regulation of cytokine secretion |
| signal transduction involved in DNA damage checkpoint |
| signal transduction involved in DNA integrity checkpoint |
| signal transduction involved in cell cycle checkpoint |
| positive regulation of mitotic cell cycle phase transition |
| regulation of epithelial cell apoptotic process |
| regulation of stress fiber assembly |
| DNA damage response, signal transduction by p53 class mediator |
| positive regulation of cell cycle arrest |
| regulation of epithelial to mesenchymal transition |
| regulation of actomyosin structure organization |
| regulation of blood vessel endothelial cell migration |
| regulation of actin filament bundle assembly |
| positive regulation of cell cycle phase transition |
| mitotic DNA damage checkpoint |
| regulation of cyclin-dependent protein serine/threonine kinase activity |
| negative regulation of G1/S transition of mitotic cell cycle |
| regulation of cyclin-dependent protein kinase activity |
| negative regulation of angiogenesis |
| signal transduction in response to DNA damage |
| mitotic DNA integrity checkpoint |
| negative regulation of blood vessel morphogenesis |
| negative regulation of cell cycle G1/S phase transition |
| regulation of cell cycle arrest |
| regulation of DNA biosynthetic process |
| negative regulation of vasculature development |
| signal transduction by p53 class mediator |
| negative regulation of epithelial cell proliferation |
| regulation of endothelial cell proliferation |
| DNA damage checkpoint |
| negative regulation of protein secretion |
| negative regulation of peptide secretion |
| positive regulation of cytokine secretion |
| DNA integrity checkpoint |
| cell cycle arrest |
| regulation of G1/S transition of mitotic cell cycle |
| cytokine production |
| positive regulation of mitotic cell cycle |
| mitotic cell cycle checkpoint |
| regulation of endothelial cell migration |
| regulation of cell cycle G1/S phase transition |
| regulation of mitotic nuclear division |
| negative regulation of cell-cell adhesion |
| complement activation |
| negative regulation of protein transport |
| negative regulation of establishment of protein localization |
| cellular response to hypoxia |
| regulation of nuclear division |
| positive regulation of DNA metabolic process |
| cell cycle checkpoint |
| positive regulation of supramolecular fiber organization |
| cellular response to decreased oxygen levels |
| negative regulation of secretion by cell |
| regulation of cytokine secretion |
| negative regulation of mitotic cell cycle phase transition |
| cellular response to oxygen levels |
| regulation of epithelial cell migration |
| positive regulation of cytoskeleton organization |
| negative regulation of cell cycle phase transition |
| negative regulation of secretion |
| negative regulation of cell migration |
| regulation of actin filament organization |
| positive regulation of DNA-binding transcription factor activity |
| positive regulation of protein secretion |
| negative regulation of cell adhesion |
| negative regulation of cell motility |
| negative regulation of cytokine production |
| positive regulation of cell cycle process |
| regulation of angiogenesis |
| positive regulation of peptide secretion |
| negative regulation of mitotic cell cycle |
| negative regulation of cellular component movement |
| regulation of vasculature development |
| negative regulation of locomotion |
| negative regulation of cell cycle process |
| activation of protein kinase activity |
| regulation of epithelial cell proliferation |
| positive regulation of protein serine/threonine kinase activity |
| regulation of actin cytoskeleton organization |
| response to hypoxia |
| humoral immune response |
| regulation of supramolecular fiber organization |
| regulation of DNA metabolic process |
| response to decreased oxygen levels |
| negative regulation of organelle organization |
| positive regulation of cell cycle |
| response to oxygen levels |
| regulation of actin filament-based process |
| regulation of cell-cell adhesion |
| positive regulation of secretion by cell |
| regulation of mitotic cell cycle phase transition |
| positive regulation of protein transport |
| regulation of DNA-binding transcription factor activity |
| positive regulation of secretion |
| regulation of cell cycle phase transition |
| positive regulation of cytokine production |
| positive regulation of establishment of protein localization |
| protein kinase binding |
| regulation of protein secretion |
| negative regulation of transport |
| centrosome |
| regulation of peptide secretion |
| regulation of protein serine/threonine kinase activity |
| positive regulation of cellular component biogenesis |
| positive regulation of protein kinase activity |
| regulation of cytoskeleton organization |
| negative regulation of cell cycle |
| positive regulation of kinase activity |
| mitotic cell cycle process |
| positive regulation of organelle organization |
| regulation of mitotic cell cycle |
| activation of immune response |
| positive regulation of apoptotic process |
| positive regulation of programmed cell death |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| mitotic cell cycle |
| regulation of cytokine production |
| positive regulation of cell death |
| negative regulation of cellular component organization |
| regulation of protein transport |
| regulation of peptide transport |
| regulation of establishment of protein localization |
| regulation of secretion by cell |
| regulation of cell cycle process |
| cellular response to DNA damage stimulus |
| regulation of protein kinase activity |
| regulation of secretion |
| regulation of cell migration |
| nucleolus |
| positive regulation of immune response |
| regulation of kinase activity |
| regulation of cell motility |
| negative regulation of developmental process |
| regulation of cellular component biogenesis |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cell cycle process |
| positive regulation of protein phosphorylation |
| regulation of protein localization |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| cell activation |
| immune effector process |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| positive regulation of immune system process |
| regulation of immune response |
| response to abiotic stimulus |
| regulation of cell cycle |
| negative regulation of multicellular organismal process |
| positive regulation of cellular component organization |
| positive regulation of transcription by RNA polymerase II |
| positive regulation of protein modification process |
| regulation of organelle organization |
| cell cycle |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| regulation of immune system process |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of protein modification process |
| regulation of transport |
| immune response |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Phenformin 20μM R05 exp212 | -2 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15151
- Expression level (log2 read counts): -7.68
Expression Distribution
RGCC Expression in NALM6 Cells: -7.68
