RNF135
Gene Information
- Official Symbol: RNF135
- Official Name: ring finger protein 135
- Aliases and Previous Symbols: N/A
- Entrez ID: 84282
- UniProt: Q8IUD6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is located in a chromosomal region known to be frequently deleted in patients with neurofibromatosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
- UniProt Summary: Acts as an E2-dependent E3 ubiquitin-protein ligase, involved in innate immune defense against viruses. Ubiquitinates DDX58 and is required for full activation of the DDX58 signaling resulting in interferon beta production. {ECO:0000269|PubMed:19017631, ECO:0000269|PubMed:19484123}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7218
- Expression level (log2 read counts): 4.33
RNF135 Expression in NALM6 Cells: 4.33
