RTCA
Gene Information
- Official Symbol: RTCA
- Official Name: RNA 3'-terminal phosphate cyclase
- Aliases and Previous Symbols: N/A
- Entrez ID: 8634
- UniProt: O00442
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA- N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15028
- Expression level (log2 read counts): 5.33
RTCA Expression in NALM6 Cells: 5.33
