RXFP1
Gene Information
- Official Symbol: RXFP1
- Official Name: relaxin family peptide receptor 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 59350
- UniProt: Q9HBX9
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011].
- UniProt Summary: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 14187
- Expression level (log2 read counts): -0.95
RXFP1 Expression in NALM6 Cells: -0.95
