S100A3
Gene Information
- Official Symbol: S100A3
- Official Name: S100 calcium binding protein A3
- Aliases and Previous Symbols: N/A
- Entrez ID: 6274
- UniProt: P33764
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has the highest content of cysteines of all S100 proteins, has a high affinity for Zinc, and is highly expressed in human hair cuticle. The precise function of this protein is unknown. [provided by RefSeq, Jul 2008].
- UniProt Summary: Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. {ECO:0000269|PubMed:18083705}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 13209
- Expression level (log2 read counts): -6.6
S100A3 Expression in NALM6 Cells: -6.6
