UniProt Summary: Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus. {ECO:0000269|PubMed:10871600, ECO:0000269|PubMed:7592909}.
Pfam DomainsGO Terms
Pfam Domains
Serpin
GO Terms
ficolin-1-rich granule membrane
serine-type endopeptidase inhibitor activity
secretory granule membrane
negative regulation of endopeptidase activity
negative regulation of peptidase activity
negative regulation of proteolysis
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
regulation of proteolysis
leukocyte mediated immunity
negative regulation of catalytic activity
exocytosis
leukocyte activation
secretion by cell
negative regulation of cellular protein metabolic process
export from cell
cell activation
immune effector process
negative regulation of protein metabolic process
secretion
negative regulation of molecular function
regulation of hydrolase activity
extracellular space
immune response
vesicle-mediated transport
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739