SERPINB3
Gene Information
- Official Symbol: SERPINB3
- Official Name: serpin family B member 3
- Aliases and Previous Symbols: N/A
- Entrez ID: 6317
- UniProt: P29508
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Serpin |
GO Terms
| paracrine signaling |
| autocrine signaling |
| negative regulation of JUN kinase activity |
| cysteine-type endopeptidase inhibitor activity |
| negative regulation of JNK cascade |
| negative regulation of stress-activated protein kinase signaling cascade |
| negative regulation of stress-activated MAPK cascade |
| positive regulation of epithelial to mesenchymal transition |
| negative regulation of MAP kinase activity |
| virus receptor activity |
| regulation of epithelial to mesenchymal transition |
| regulation of JUN kinase activity |
| azurophil granule lumen |
| viral entry into host cell |
| serine-type endopeptidase inhibitor activity |
| entry into host |
| entry into host cell |
| protease binding |
| negative regulation of protein serine/threonine kinase activity |
| vesicle |
| interaction with host |
| negative regulation of MAPK cascade |
| positive regulation of endopeptidase activity |
| regulation of JNK cascade |
| positive regulation of peptidase activity |
| viral life cycle |
| negative regulation of protein kinase activity |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| negative regulation of endopeptidase activity |
| negative regulation of kinase activity |
| cytoplasmic vesicle |
| negative regulation of peptidase activity |
| negative regulation of transferase activity |
| regulation of MAP kinase activity |
| negative regulation of proteolysis |
| positive regulation of proteolysis |
| negative regulation of protein phosphorylation |
| regulation of endopeptidase activity |
| negative regulation of phosphorylation |
| regulation of peptidase activity |
| negative regulation of hydrolase activity |
| neutrophil degranulation |
| neutrophil activation involved in immune response |
| neutrophil mediated immunity |
| positive regulation of cell migration |
| neutrophil activation |
| granulocyte activation |
| negative regulation of intracellular signal transduction |
| leukocyte degranulation |
| regulation of protein serine/threonine kinase activity |
| myeloid leukocyte mediated immunity |
| positive regulation of cell motility |
| myeloid cell activation involved in immune response |
| positive regulation of cellular component movement |
| positive regulation of locomotion |
| negative regulation of phosphate metabolic process |
| negative regulation of phosphorus metabolic process |
| myeloid leukocyte activation |
| negative regulation of protein modification process |
| leukocyte activation involved in immune response |
| cell activation involved in immune response |
| viral process |
| regulated exocytosis |
| regulation of proteolysis |
| regulation of cellular response to stress |
| regulation of MAPK cascade |
| leukocyte mediated immunity |
| positive regulation of hydrolase activity |
| symbiotic process |
| negative regulation of catalytic activity |
| exocytosis |
| regulation of protein kinase activity |
| interspecies interaction between organisms |
| regulation of cell migration |
| regulation of kinase activity |
| regulation of cell motility |
| positive regulation of cell population proliferation |
| leukocyte activation |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| regulation of locomotion |
| regulation of cellular component movement |
| secretion by cell |
| negative regulation of cellular protein metabolic process |
| export from cell |
| cell activation |
| immune effector process |
| negative regulation of protein metabolic process |
| cell-cell signaling |
| secretion |
| negative regulation of molecular function |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of response to stress |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| immune response |
| extracellular region |
| vesicle-mediated transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| THZ531 0.11μM R07 exp409 | -1.87 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9370
- Expression level (log2 read counts): -7.68
Expression Distribution
SERPINB3 Expression in NALM6 Cells: -7.68
