SERPINB9
Gene Information
- Official Symbol: SERPINB9
- Official Name: serpin family B member 9
- Aliases and Previous Symbols: N/A
- Entrez ID: 5272
- UniProt: P50453
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Granzyme B inhibitor.
Pfam Domains GO Terms
Pfam Domains
| Serpin |
GO Terms
| negative regulation by symbiont of host programmed cell death |
| protection from natural killer cell mediated cytotoxicity |
| negative regulation by symbiont of host apoptotic process |
| modulation by organism of apoptotic process in other organism involved in symbiotic interaction |
| modulation of programmed cell death in other organism |
| modulation of programmed cell death in other organism involved in symbiotic interaction |
| modulation of apoptotic process in other organism |
| modulation by symbiont of host apoptotic process |
| modulation by symbiont of host programmed cell death |
| negative regulation of natural killer cell mediated cytotoxicity |
| cellular response to estrogen stimulus |
| negative regulation of natural killer cell mediated immunity |
| negative regulation of leukocyte mediated cytotoxicity |
| mast cell mediated immunity |
| negative regulation of cell killing |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| modulation by symbiont of host cellular process |
| negative regulation of lymphocyte mediated immunity |
| modification by symbiont of host morphology or physiology |
| regulation of natural killer cell mediated cytotoxicity |
| regulation of natural killer cell mediated immunity |
| negative regulation of leukocyte mediated immunity |
| negative regulation of innate immune response |
| response to estrogen |
| regulation of leukocyte mediated cytotoxicity |
| negative regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of cysteine-type endopeptidase activity |
| negative regulation of response to biotic stimulus |
| serine-type endopeptidase inhibitor activity |
| regulation of cell killing |
| protease binding |
| modification of morphology or physiology of other organism involved in symbiotic interaction |
| negative regulation of immune effector process |
| negative regulation of immune response |
| regulation of lymphocyte mediated immunity |
| modification of morphology or physiology of other organism |
| interaction with host |
| regulation of leukocyte mediated immunity |
| negative regulation of defense response |
| regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| negative regulation of multi-organism process |
| regulation of cysteine-type endopeptidase activity |
| negative regulation of endopeptidase activity |
| negative regulation of peptidase activity |
| negative regulation of proteolysis |
| negative regulation of response to external stimulus |
| collagen-containing extracellular matrix |
| regulation of endopeptidase activity |
| negative regulation of immune system process |
| regulation of peptidase activity |
| regulation of innate immune response |
| negative regulation of hydrolase activity |
| regulation of immune effector process |
| myeloid leukocyte mediated immunity |
| regulation of response to biotic stimulus |
| response to bacterium |
| regulation of proteolysis |
| regulation of defense response |
| leukocyte mediated immunity |
| regulation of multi-organism process |
| symbiotic process |
| negative regulation of catalytic activity |
| interspecies interaction between organisms |
| negative regulation of apoptotic process |
| negative regulation of programmed cell death |
| apoptotic process |
| Golgi apparatus |
| negative regulation of cell death |
| negative regulation of cellular protein metabolic process |
| programmed cell death |
| cell death |
| immune effector process |
| regulation of response to external stimulus |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| regulation of immune response |
| regulation of hydrolase activity |
| response to other organism |
| response to external biotic stimulus |
| response to biotic stimulus |
| regulation of response to stress |
| regulation of apoptotic process |
| regulation of programmed cell death |
| extracellular space |
| negative regulation of response to stimulus |
| regulation of immune system process |
| regulation of cell death |
| immune response |
| positive regulation of gene expression |
| membrane |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Asunaprenir 3μM R07 exp336 | -1.75 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 11730
- Expression level (log2 read counts): 5.24
Expression Distribution
SERPINB9 Expression in NALM6 Cells: 5.24
