SF3B14

• Official Symbol: N/A
• Official Name: N/A
• Aliases and Previous Symbols: N/A
• Entrez ID: N/A
• UniProt: N/A
• Interactions: BioGRID
• PubMed articles: Open PubMed
• OMIM: N/A

• Entrez Summary: N/A
• UniProt Summary: Involved in pre-mRNA splicing as a component of the splicing factor SF3B complex (PubMed:27720643). SF3B complex is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA (PubMed:12234937). Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively (PubMed:16432215). {ECO:0000269|PubMed:12234937, ECO:0000269|PubMed:16432215, ECO:0000269|PubMed:27720643}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

• Essentiality Rank: 2885
• Expression level (log2 read counts): N/A

Expression Distribution

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NA Expression in NALM6 Cells: N/A