SGK1
Gene Information
- Official Symbol: SGK1
- Official Name: serum/glucocorticoid regulated kinase 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6446
- UniProt: O00141
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Pkinase C |
| Pkinase Tyr |
| Pkinase |
GO Terms
| renal sodium ion absorption |
| renal sodium ion transport |
| chloride channel regulator activity |
| regulation of gastric acid secretion |
| renal absorption |
| protein serine/threonine/tyrosine kinase activity |
| long-term memory |
| sodium channel regulator activity |
| calcium channel regulator activity |
| regulation of digestive system process |
| potassium channel regulator activity |
| renal system process |
| positive regulation of transporter activity |
| memory |
| sodium ion transport |
| peptidyl-serine phosphorylation |
| regulation of blood pressure |
| peptidyl-serine modification |
| learning or memory |
| regulation of transporter activity |
| cognition |
| protein serine/threonine kinase activity |
| blood circulation |
| circulatory system process |
| monovalent inorganic cation transport |
| nuclear speck |
| regulation of cell growth |
| regulation of DNA-binding transcription factor activity |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cell part morphogenesis |
| behavior |
| regulation of system process |
| metal ion transport |
| neuron projection development |
| regulation of growth |
| cell morphogenesis |
| cellular response to DNA damage stimulus |
| regulation of secretion |
| neuron development |
| cellular component morphogenesis |
| cation transport |
| regulation of cell migration |
| peptidyl-amino acid modification |
| regulation of cell motility |
| apoptotic process |
| endoplasmic reticulum membrane |
| ion transmembrane transport |
| protein phosphorylation |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| neuron differentiation |
| programmed cell death |
| cell death |
| plasma membrane bounded cell projection organization |
| cell projection organization |
| mitochondrion |
| transmembrane transport |
| phosphorylation |
| ion transport |
| nervous system process |
| ATP binding |
| generation of neurons |
| regulation of apoptotic process |
| regulation of programmed cell death |
| regulation of cell population proliferation |
| neurogenesis |
| cell development |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of molecular function |
| regulation of transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Hippuristanol 0.12μM R08 exp489 no dilution day6 | 1.76 |
| Nifurtimox 1μM R03 exp141 | 1.86 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 1/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 12216
- Expression level (log2 read counts): 2.0
Expression Distribution
SGK1 Expression in NALM6 Cells: 2.0
