SH3BP2
Gene Information
- Official Symbol: SH3BP2
- Official Name: SH3 domain binding protein 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6452
- UniProt: P78314
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene has an N-terminal pleckstrin homology (PH) domain, an SH3-binding proline-rich region, and a C-terminal SH2 domain. The protein binds to the SH3 domains of several proteins including the ABL1 and SYK protein tyrosine kinases , and functions as a cytoplasmic adaptor protein to positively regulate transcriptional activity in T, natural killer (NK), and basophilic cells. Mutations in this gene result in cherubism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
- UniProt Summary: N/A
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 12553
- Expression level (log2 read counts): 5.54
SH3BP2 Expression in NALM6 Cells: 5.54
