SHC1
Gene Information
- Official Symbol: SHC1
- Official Name: SHC adaptor protein 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 6464
- UniProt: P29353
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| SH2 |
| PID |
GO Terms
| Shc-EGFR complex |
| epidermal growth factor binding |
| neurotrophin TRKA receptor binding |
| interleukin-2-mediated signaling pathway |
| cellular response to interleukin-2 |
| cellular response to interleukin-15 |
| transmembrane receptor protein tyrosine kinase adaptor activity |
| response to interleukin-2 |
| interleukin-15-mediated signaling pathway |
| response to interleukin-15 |
| insulin-like growth factor receptor binding |
| insulin receptor binding |
| regulation of epidermal growth factor-activated receptor activity |
| ephrin receptor binding |
| ERBB2 signaling pathway |
| epidermal growth factor receptor binding |
| phosphotyrosine residue binding |
| epidermal growth factor receptor signaling pathway |
| IRE1-mediated unfolded protein response |
| receptor tyrosine kinase binding |
| positive regulation of Ras protein signal transduction |
| actin cytoskeleton reorganization |
| ERBB signaling pathway |
| positive regulation of small GTPase mediated signal transduction |
| regulation of epidermal growth factor receptor signaling pathway |
| insulin receptor signaling pathway |
| regulation of protein tyrosine kinase activity |
| regulation of ERBB signaling pathway |
| endoplasmic reticulum unfolded protein response |
| phospholipid binding |
| cellular response to unfolded protein |
| cellular response to topologically incorrect protein |
| activation of MAPK activity |
| response to unfolded protein |
| cellular response to insulin stimulus |
| regulation of signaling receptor activity |
| Fc-epsilon receptor signaling pathway |
| response to topologically incorrect protein |
| positive regulation of ERK1 and ERK2 cascade |
| response to insulin |
| Fc receptor signaling pathway |
| regulation of Ras protein signal transduction |
| Ras protein signal transduction |
| regulation of peptidyl-tyrosine phosphorylation |
| response to endoplasmic reticulum stress |
| axon guidance |
| neuron projection guidance |
| positive regulation of MAP kinase activity |
| cellular response to peptide hormone stimulus |
| regulation of ERK1 and ERK2 cascade |
| angiogenesis |
| small GTPase mediated signal transduction |
| cellular response to peptide |
| activation of protein kinase activity |
| defense response to bacterium |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| regulation of small GTPase mediated signal transduction |
| mitochondrial matrix |
| MAPK cascade |
| axonogenesis |
| leukocyte migration |
| response to peptide hormone |
| signal transduction by protein phosphorylation |
| blood vessel morphogenesis |
| axon development |
| cell morphogenesis involved in neuron differentiation |
| response to peptide |
| neuron projection morphogenesis |
| immune response-regulating cell surface receptor signaling pathway |
| plasma membrane bounded cell projection morphogenesis |
| blood vessel development |
| cell projection morphogenesis |
| actin cytoskeleton organization |
| cellular response to growth factor stimulus |
| cell-cell adhesion |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| cell part morphogenesis |
| regulation of protein serine/threonine kinase activity |
| cardiovascular system development |
| heart development |
| response to growth factor |
| positive regulation of protein kinase activity |
| positive regulation of MAPK cascade |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| actin filament-based process |
| positive regulation of kinase activity |
| immune response-regulating signaling pathway |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| tube morphogenesis |
| positive regulation of transferase activity |
| cellular response to nitrogen compound |
| neuron projection development |
| regulation of growth |
| cytokine-mediated signaling pathway |
| response to bacterium |
| viral process |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| regulation of MAPK cascade |
| symbiotic process |
| regulation of protein kinase activity |
| neuron development |
| interspecies interaction between organisms |
| cellular component morphogenesis |
| tube development |
| circulatory system development |
| regulation of kinase activity |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| positive regulation of cell population proliferation |
| cell adhesion |
| biological adhesion |
| defense response to other organism |
| cell migration |
| protein phosphorylation |
| regulation of transferase activity |
| negative regulation of cell death |
| response to organonitrogen compound |
| cellular response to cytokine stimulus |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| localization of cell |
| cell motility |
| response to nitrogen compound |
| response to cytokine |
| cytoskeleton organization |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphorus metabolic process |
| positive regulation of phosphate metabolic process |
| regulation of immune response |
| cell projection organization |
| negative regulation of transcription, DNA-templated |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| phosphorylation |
| response to other organism |
| response to external biotic stimulus |
| locomotion |
| response to biotic stimulus |
| negative regulation of RNA metabolic process |
| defense response |
| negative regulation of cellular macromolecule biosynthetic process |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| generation of neurons |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| movement of cell or subcellular component |
| response to oxygen-containing compound |
| regulation of programmed cell death |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of immune system process |
| positive regulation of signal transduction |
| regulation of cell death |
| intracellular signal transduction |
| cellular response to stress |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 1/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 2879
- Expression level (log2 read counts): 5.03
Expression Distribution
SHC1 Expression in NALM6 Cells: 5.03
