UniProt Summary: Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. {ECO:0000269|PubMed:19383767}.
Pfam DomainsGO Terms
Pfam Domains
SHQ1
GO Terms
box H/ACA snoRNP assembly
negative regulation of rRNA processing
negative regulation of ribosome biogenesis
small nucleolar ribonucleoprotein complex assembly
regulation of rRNA processing
regulation of ribosome biogenesis
positive regulation of telomerase RNA localization to Cajal body
regulation of telomerase RNA localization to Cajal body
Cajal body
unfolded protein binding
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribonucleoprotein complex biogenesis
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of cell death
cellular protein-containing complex assembly
nucleolus
regulation of cellular component biogenesis
negative regulation of RNA metabolic process
negative regulation of nucleobase-containing compound metabolic process
regulation of apoptotic process
protein-containing complex assembly
regulation of programmed cell death
regulation of cell death
negative regulation of gene expression
protein-containing complex subunit organization
CRISPR Data
Compound HitMost Correlated Genes in ChemogenomicsTissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 527/739