SIGLEC11
Gene Information
- Official Symbol: SIGLEC11
- Official Name: sialic acid binding Ig like lectin 11
- Aliases and Previous Symbols: N/A
- Entrez ID: 114132
- UniProt: Q96RL6
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
- UniProt Summary: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 4838
- Expression level (log2 read counts): 1.93
SIGLEC11 Expression in NALM6 Cells: 1.93
