SIL1
Gene Information
- Official Symbol: SIL1
- Official Name: SIL1 nucleotide exchange factor
- Aliases and Previous Symbols: N/A
- Entrez ID: 64374
- UniProt: Q9H173
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a resident endoplasmic reticulum (ER), N-linked glycoprotein with an N-terminal ER targeting sequence, 2 putative N-glycosylation sites, and a C-terminal ER retention signal. This protein functions as a nucleotide exchange factor for another unfolded protein response protein. Mutations in this gene have been associated with Marinesco-Sjogren syndrome. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008].
- UniProt Summary: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000269|PubMed:12356756}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7211
- Expression level (log2 read counts): 4.25
SIL1 Expression in NALM6 Cells: 4.25
