SLC10A2
Gene Information
- Official Symbol: SLC10A2
- Official Name: solute carrier family 10 member 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 6555
- UniProt: Q12908
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene encodes a sodium/bile acid cotransporter. This transporter is the primary mechanism for uptake of intestinal bile acids by apical cells in the distal ileum. Bile acids are the catabolic product of cholesterol metabolism, so this protein is also critical for cholesterol homeostasis. Mutations in this gene cause primary bile acid malabsorption (PBAM); muatations in this gene may also be associated with other diseases of the liver and intestines, such as familial hypertriglyceridemia (FHTG). [provided by RefSeq, Mar 2010].
- UniProt Summary: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine. Plays a key role in cholesterol metabolism.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 15119
- Expression level (log2 read counts): -2.51
SLC10A2 Expression in NALM6 Cells: -2.51
