SLC17A7
Gene Information
- Official Symbol: SLC17A7
- Official Name: solute carrier family 17 member 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 57030
- UniProt: Q9P2U7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. {ECO:0000269|PubMed:10820226}.
Pfam Domains GO Terms
Pfam Domains
| MFS 1 |
GO Terms
| extracellularly glutamate-gated chloride channel activity |
| synaptic vesicle lumen acidification |
| sequestering of neurotransmitter |
| sodium:inorganic phosphate symporter activity |
| clathrin-sculpted glutamate transport vesicle membrane |
| sodium-dependent phosphate transmembrane transporter activity |
| sodium-dependent phosphate transport |
| cerebellar mossy fiber |
| neurotransmitter transmembrane transporter activity |
| neurotransmitter loading into synaptic vesicle |
| L-glutamate import |
| L-glutamate transmembrane transporter activity |
| synaptic vesicle maturation |
| regulation of synaptic vesicle endocytosis |
| L-glutamate transmembrane transport |
| amino acid import |
| phosphate ion transport |
| regulation of synaptic vesicle recycling |
| synaptic transmission, glutamatergic |
| glutamate secretion |
| excitatory synapse |
| long-term memory |
| neuron cellular homeostasis |
| integral component of synaptic vesicle membrane |
| presynaptic active zone |
| L-alpha-amino acid transmembrane transport |
| acidic amino acid transport |
| neural retina development |
| L-amino acid transport |
| excitatory postsynaptic potential |
| chemical synaptic transmission, postsynaptic |
| synaptic vesicle membrane |
| drug transmembrane transport |
| amino acid transmembrane transport |
| dicarboxylic acid transport |
| acid secretion |
| postsynapse |
| chloride transmembrane transport |
| sodium ion transmembrane transport |
| regulation of postsynaptic membrane potential |
| chloride transport |
| inorganic anion transmembrane transport |
| regulation of synaptic vesicle cycle |
| memory |
| amino acid transport |
| synaptic vesicle cycle |
| carboxylic acid transmembrane transport |
| organic acid transmembrane transport |
| vesicle-mediated transport in synapse |
| retina development in camera-type eye |
| proton transmembrane transport |
| drug transport |
| sodium ion transport |
| inorganic anion transport |
| maintenance of location |
| neurotransmitter transport |
| regulation of endocytosis |
| regulation of synapse structure or activity |
| developmental maturation |
| learning or memory |
| anion transmembrane transport |
| organic acid transport |
| carboxylic acid transport |
| cognition |
| vesicle organization |
| camera-type eye development |
| anatomical structure homeostasis |
| regulation of neurotransmitter levels |
| eye development |
| visual system development |
| sensory system development |
| monovalent inorganic cation transport |
| chemical synaptic transmission |
| anterograde trans-synaptic signaling |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| regulation of membrane potential |
| trans-synaptic signaling |
| organic anion transport |
| synaptic signaling |
| sensory organ development |
| cell junction |
| regulation of vesicle-mediated transport |
| inorganic cation transmembrane transport |
| behavior |
| anion transport |
| cation transmembrane transport |
| metal ion transport |
| inorganic ion transmembrane transport |
| brain development |
| head development |
| cation transport |
| cellular homeostasis |
| regulation of cellular localization |
| ion transmembrane transport |
| central nervous system development |
| secretion by cell |
| response to drug |
| export from cell |
| cell-cell signaling |
| secretion |
| transmembrane transport |
| ion transport |
| nervous system process |
| homeostatic process |
| establishment of localization in cell |
| nitrogen compound transport |
| regulation of transport |
| vesicle-mediated transport |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 9750
- Expression level (log2 read counts): 1.11
Expression Distribution
SLC17A7 Expression in NALM6 Cells: 1.11
