SLC22A18
Gene Information
- Official Symbol: SLC22A18
- Official Name: solute carrier family 22 member 18
- Aliases and Previous Symbols: N/A
- Entrez ID: 5002
- UniProt: Q96BI1
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: N/A
Function Summary
- Entrez Summary: This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015].
- UniProt Summary: May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney. {ECO:0000269|PubMed:9744804}.
CRISPR Data
Essentiality in NALM6
- Essentiality Rank: 7397
- Expression level (log2 read counts): 1.9
SLC22A18 Expression in NALM6 Cells: 1.9
